Photovoltaic (PV) system diagnosis is a growing research domain likewise solar energy’s ongoing significant expansion. Indeed, efficient Fault Detection and Diagnosis (FDD) tools are crucial to guarantee reliability, avoid premature aging and improve the profitability of PV plants. In this paper, an on-line diagnosis method using the PV plant electrical output is presented. This entirely signal-based method combines variational mode decomposition (VMD) and multiscale dispersion entropy (MDE) for the purpose of detecting and isolating faults in a real grid-connected PV plant. The present method seeks a low-cost design, an ease of implementation and a low computation cost. Taking into account the innovation of applying these techniques to PV FDD, the VMD and MDE procedures as well as parameters identification are carefully detailed. The proposed FFD approach performance is assessed on a real rooftop PV plant with experimentally induced faults, and the first results reveal the MDE approach has good suitability for PV plants diagnosis.