Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp

Abstract : Seven new nitrogenous macrolides, designated salarins D-J, closely related to salarins A-C, were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structure and relative stereochem. of salarins D-J were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY spectra. Salarin B's structure, based on the structure of salarin J, is now amended to also incorporate the C-14 to -17 THF ring system. All compds. were evaluated for their cytotoxicity against K562 and UT-7 human leukemia cells. While salarins D, E, H, and J displayed dose- and time-dependent inhibition of proliferation, salarins F and I were not active in these assays. [on SciFinder(R)]
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https://hal.univ-reunion.fr/hal-01188129
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Submitted on : Friday, August 28, 2015 - 3:07:18 PM
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Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, et al.. Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp. Tetrahedron, Elsevier, 2010, 66 (24), pp.4339--4345. ⟨10.1016/j.tet.2010.04.035⟩. ⟨hal-01188129⟩

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