Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp
Résumé
Seven new nitrogenous macrolides, designated salarins D-J, closely related to salarins A-C, were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structure and relative stereochem. of salarins D-J were elucidated by interpretation of MS, COSY, HSQC, HMBC, and NOESY spectra. Salarin B's structure, based on the structure of salarin J, is now amended to also incorporate the C-14 to -17 THF ring system. All compds. were evaluated for their cytotoxicity against K562 and UT-7 human leukemia cells. While salarins D, E, H, and J displayed dose- and time-dependent inhibition of proliferation, salarins F and I were not active in these assays. [on SciFinder(R)]