The behavior of ozone gas (O 3 ) in the atmosphere varies according to the region of the globe. Its formation occurs mainly in the tropical stratosphere through the photodissociation of molecular oxygen with the aid of the incidence of ultraviolet solar radiation. Still, the highest concentrations of O 3 content are found in high-latitude regions (poles) due to the Brewer-Dobson circulation, a large-scale circulation that takes place from the tropics to the pole in the winter hemisphere. This work presents a multi-instrumental analysis at two Brazilian sites, a subtropical one (Santa Maria -29.72°S, 53.41°W) and an equatorial one (Natal -5.4°S, 35.4°W), to investigate ozone distributions in terms of vertical profiles (2002-2020) and total abundance in terms of total columns of ozone (1979-2020). The study is based on the use of ground-based and satellite observations. Ozone profiles over Natal, from the ground up to the mesosphere, are obtained by radiosonde experiments (0-30 km) in the framework of the SHADOZ program and by satellite measurements from the SABER instrument (15-60 km). This enabled the construction of a continuous time series for ozone, including monthly values and climatological trends. There is a good agreement between the two measurements in the common observation layer, mainly for altitudes above 20 km. Below 20 km, SABER ozone profiles showed high variability and overestimated ozone mixing ratios by over 50 %. Dynamic and photochemical effects can interfere with O 3 for-mation and distribution along higher latitudes through the Brewer-Dobson circulation. The measurements of the total ozone columns used are in good agreement with each other (TOMS/OMI × Dobson for Natal and TOMS/OMI × Brewer for Santa Maria) in time and space, in line with previous studies for these latitudes. Wavelet analysis was used over 42 years. The investigation revealed a significant annual cycle in both data series for both sites. The study highlighted that the quasi-biennial oscillation (QBO) plays a significant role in the variability of stratospheric ozone at the two study sites -Natal and Santa Maria. The QBO's contribution was found to be stronger at the Equator (Natal) than at the subtropics (Santa Maria). Additionally, the study showed that the 11-year solar cycle also has a significant impact on ozone variability at both locations. Given the study latitudes, the ozone variations observed at the two sites showed different patterns and amounts. Only a limited number of studies have been conducted on stratospheric ozone in South America, particularly in the region between the Equator and the subtropics. The primary aim of this work is to investigate the behavior of stratospheric ozone at various altitudes and latitudes using ground-based and satellite measurements in terms of vertical profiles and total columns of ozone.