Use of ADAM‐C and CHA2DS2‐VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study - Université de La Réunion Access content directly
Journal Articles Echocardiography Year : 2021

Use of ADAM‐C and CHA2DS2‐VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study

Christophe Jego
  • Function : Author
Ulric Vinsonneau
  • Function : Author
Philippe Garçon
  • Function : Author
Guillaume Turlotte
  • Function : Author
Jean François Rivière
  • Function : Author
Marion Maurin
  • Function : Author
Rémy Lubret
  • Function : Author
Patrick Meimoun
  • Function : Author
Chrystelle Akret
  • Function : Author
Charles Sokic
  • Function : Author
Laurent Michel
  • Function : Author
Maryse Lescure
  • Function : Author
Marie Melay
  • Function : Author
Maxime Fayard
  • Function : Author
Anthony Chauvat
  • Function : Author
Renaud Fouché
  • Function : Author
Guillaume Cartigny
  • Function : Author
Nicolas Dijoux
  • Function : Author
Anne Céline Martin
  • Function : Author
Aurélia Tho-Agostini
  • Function : Author
Hubert Mann
  • Function : Author
Dominique Magnin
  • Function : Author
Marc Goralski
  • Function : Author
Fernando Pico
  • Function : Author
Jean‐louis Georges
  • Function : Author
Loïc Belle
  • Function : Author

Abstract

Background and aims Complex aortic atheroma (CAA) is a common cause of acute brain ischemia (BI), including ischemic stroke (IS) and transient ischemic attack (TIA), and is associated with recurrence. The CHA2DS2‐VASc score is a useful tool for predicting stroke in patients with atrial fibrillation (AF), and can also predict cardiovascular events in other populations, including non‐AF populations. The ADAM‐C score is a new risk score for predicting the diagnostic yield of transesophageal echocardiography (TEE) after BI. We aimed to evaluate the ability of CHA2DS2‐VASc and ADAM‐C scores to predict CAA after BI. Methods This prospective, multicenter, observational study included 1479 patients aged over 18 years who were hospitalized for BI. CAA was defined as the presence of one or more of the following criteria: thrombus, ulcerated plaque, or plaque thickening ≥ 4 mm. Results CAA was diagnosed in 216 patients (14.6%). CHA2DS2‐VASc and ADAM‐C scores were significantly higher in the CAA group versus the non‐CAA group ( P < .0001 for both). The CHA2DS2‐VASc and ADAM‐C scores appear to be good predictors of CAA (AUC 0.699 [0.635, 0.761] and 0.759 [0.702, 0.814], respectively). The sensitivity, specificity, predictive positive value (PPV), and negative predictive value (NPV) of the scores for detecting CAA were 94%, 22%, 17%, and 96%, respectively, for a CHA2DS2‐VASc score < 2, and 90%, 46%, 22%, and 96%, respectively, for an ADAM‐C score < 3 Conclusions CHA2DS2‐VASc and ADAM‐C scores are able to predict CAA after BI. CHA2DS2‐VASc < 2 and ADAM‐C < 3 both have an interesting NPV of 96%.
No file

Dates and versions

hal-04540891 , version 1 (10-04-2024)

Identifiers

Cite

Florence Nicot, Clément Charbonnel, Christophe Jego, François Jourda, Ulric Vinsonneau, et al.. Use of ADAM‐C and CHA2DS2‐VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study. Echocardiography, 2021, 38 (4), pp.612-622. ⟨10.1111/echo.15034⟩. ⟨hal-04540891⟩
3 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More