Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain - Université de La Réunion Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2022

Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain

Abstract

Zebrafish has become a popular model to study many physiological and pathophysiological processes in humans. In recent years, it has rapidly emerged in the study of metabolic disorders, namely, obesity and diabetes, as the regulatory mechanisms and metabolic pathways of glucose and lipid homeostasis are highly conserved between fish and mammals. Zebrafish is also widely used in the field of neurosciences to study brain plasticity and regenerative mechanisms due to the high maintenance and activity of neural stem cells during adulthood. Recently, a large body of evidence has established that metabolic disorders can alter brain homeostasis, leading to neuro-inflammation and oxidative stress and causing decreased neurogenesis. To date, these pathological metabolic conditions are also risk factors for the development of cognitive dysfunctions and neurodegenerative diseases. In this review, we first aim to describe the main metabolic models established in zebrafish to demonstrate their similarities with their respective mammalian/human counterparts. Then, in the second part, we report the impact of metabolic disorders (obesity and diabetes) on brain homeostasis with a particular focus on the blood-brain barrier, neuro-inflammation, oxidative stress, cognitive functions and brain plasticity. Finally, we propose interesting signaling pathways and regulatory mechanisms to be explored in order to better understand how metabolic disorders can negatively impact neural stem cell activity.
Fichier principal
Vignette du fichier
ijms-23-05372-v2.pdf (1.81 Mo) Télécharger le fichier
Origin Publication funded by an institution
Licence

Dates and versions

hal-04227814 , version 1 (04-10-2023)

Licence

Identifiers

Cite

Batoul Ghaddar, Nicolas Diotel. Zebrafish: A New Promise to Study the Impact of Metabolic Disorders on the Brain. International Journal of Molecular Sciences, 2022, 23 (10), pp.5372. ⟨10.3390/ijms23105372⟩. ⟨hal-04227814⟩
26 View
26 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More