Skip to Main content Skip to Navigation
Journal articles

Zika Virus Growth in Human Kidney Cells Is Restricted by an Elevated Glucose Level

Abstract : Mosquito-borne Zika virus (ZIKV) became a real threat to human health due to the lack of vaccine and effective antiviral treatment. The virus has recently been responsible for a global outbreak leading to millions of infected cases. ZIKV complications were highlighted in adults with Guillain–Barré syndrome and in newborns with increasing numbers of congenital disorders ranging from mild developmental delays to fatal conditions. The ability of ZIKV to establish a long-term infection in diverse organs including the kidneys has been recently documented but the consequences of such a viral infection are still debated. Our study aimed to determine whether the efficiency of ZIKV growth in kidney cells relates to glucose concentration. Human kidney HK-2 cells were infected with different ZIKV strains in presence of normal and high glucose concentrations. Virological assays showed a decrease in viral replication without modifying entry steps (viral binding, internalization, fusion) under high glucose conditions. This decrease replication was associated with a lower virus progeny and increased cell viability when compared to ZIKV-infected HK-2 cells in normal glucose concentration. In conclusion, we showed for the first time that an elevated glucose level influences ZIKV replication level with an effect on kidney cell survival.
Document type :
Journal articles
Complete list of metadata
Contributor : Réunion Univ Connect in order to contact the contributor
Submitted on : Thursday, June 23, 2022 - 2:28:55 PM
Last modification on : Monday, June 27, 2022 - 2:26:42 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Alawiya Reslan, Juliano G Haddad, Liadrine Moukendza Koundi, Philippe Desprès, Jean-Loup Bascands, et al.. Zika Virus Growth in Human Kidney Cells Is Restricted by an Elevated Glucose Level. International Journal of Molecular Sciences, MDPI, 2021, 22, ⟨10.3390/ijms22052495⟩. ⟨hal-03702890⟩



Record views


Files downloads