Skip to Main content Skip to Navigation
Journal articles

Deciphering SARS-CoV-2 Virologic and Immunologic Features

Abstract : Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated pathology, COVID-19, have been of particular concerns these last months due to the worldwide burden they represent. The number of cases requiring intensive care being the critical point in this epidemic, a better understanding of the pathophysiology leading to these severe cases is urgently needed. Tissue lesions can be caused by the pathogen or can be driven by an overwhelmed immune response. Focusing on SARS-CoV-2, we and others have observed that this virus can trigger indeed an immune response that can be dysregulated in severe patients and leading to further injury to multiple organs. The purpose of the review is to bring to light the current knowledge about SARS-CoV-2 virologic and immunologic features. Thus, we address virus biology, life cycle, tropism for many organs and how ultimately it will affect several host biological and physiological functions, notably the immune response. Given that therapeutic avenues are now highly warranted, we also discuss the immunotherapies available to manage the infection and the clinical outcomes.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-reunion.fr/hal-03066442
Contributor : Réunion Univ <>
Submitted on : Tuesday, December 15, 2020 - 12:11:42 PM
Last modification on : Wednesday, June 30, 2021 - 9:40:16 PM
Long-term archiving on: : Tuesday, March 16, 2021 - 7:22:16 PM

File

ijms-21-05932-v2.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Grégorie Lebeau, Damien Vagner, Étienne Frumence, Franck Ah-Pine, Xavier Guillot, et al.. Deciphering SARS-CoV-2 Virologic and Immunologic Features. International Journal of Molecular Sciences, MDPI, 2020, 21 (16), pp.5932. ⟨10.3390/ijms21165932⟩. ⟨hal-03066442⟩

Share

Metrics

Record views

71

Files downloads

169