HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Abstract : Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA replicon with the Green Fluorescent Protein (GFP) as a reporter protein, we were able to show that HO-1 expression resulted in the inhibition of viral RNA replication. Conversely, we observed a decrease in HO-1 expression in cells replicating the ZIKV RNA replicon. The study of human cells infected with ZIKV showed that the HO-1 expression level was significantly lower once viral replication was established, thereby limiting the antiviral effect of HO-1. Our work highlights the capacity of ZIKV to thwart the anti-replicative activity of HO-1 in human cells. Therefore, the modulation of HO-1 as a novel therapeutic strategy against ZIKV infection may display limited effect.
Complete list of metadata

Cited literature [31 references]  Display  Hide  Download

https://hal.univ-reunion.fr/hal-02981535
Contributor : Réunion Univ Connect in order to contact the contributor
Submitted on : Wednesday, October 28, 2020 - 9:38:44 AM
Last modification on : Wednesday, May 11, 2022 - 3:26:01 PM
Long-term archiving on: : Friday, January 29, 2021 - 6:14:22 PM

File

viruses-11-00002.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - ShareAlike 4.0 International License

Identifiers

Collections

Citation

Chaker El Kalamouni, Étienne Frumence, Sandra Bos, Jonathan Turpin, Brice Nativel, et al.. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses, MDPI, 2018, New Advances on Zika Virus Research, 11 (1), ⟨10.3390/v11010002⟩. ⟨hal-02981535⟩

Share

Metrics

Record views

55

Files downloads

50