Enhanced oxidative stress in adipose tissue from diabetic mice, possible contribution of glycated albumin

Abstract : Although enhanced oxidative stress and proteotoxicity constitute major contributors to the pathogenesis of multiple diseases, there is limited understanding of its role in adipose tissue. Here, we aimed at evaluating oxidative stress biomarkers in adipocytes from diabetic/obese db/db mice. The current study revealed that reactive oxygen species production was upregulated in adipocytes, together with lipid peroxidation 4-hydroxynonenal accumulation, and altered proteolytic and antioxidant activities. In parallel, acute exposure of 3T3L1 adipocyte cell lines to glycated albumin (known to be enhanced with diabetes) also elicited intracellular free radical formation. Our data provide novel insights into redox and proteolytic homeostasis in adipocytes.
Document type :
Journal articles
Complete list of metadatas

Cited literature [25 references]  Display  Hide  Download

http://hal.univ-reunion.fr/hal-01692746
Contributor : Réunion Univ <>
Submitted on : Tuesday, February 6, 2018 - 1:41:16 PM
Last modification on : Tuesday, September 3, 2019 - 1:18:01 PM
Long-term archiving on : Friday, May 25, 2018 - 7:30:46 PM

File

2016 - Enhanced oxidative stre...
Files produced by the author(s)

Identifiers

Collections

Citation

Florence Boyer, Nicolas Diotel, Dorothée Girard, Philippe Rondeau, M. Faadiel Essop, et al.. Enhanced oxidative stress in adipose tissue from diabetic mice, possible contribution of glycated albumin. Biochemical and Biophysical Research Communications, Elsevier, 2016, 473 (1), pp.154-160. ⟨10.1016/j.bbrc.2016.03.068⟩. ⟨hal-01692746⟩

Share

Metrics

Record views

147

Files downloads

144