Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

Stella G. Muthuri; Sudhir Venkatesan; Puja R. Myles; Jo Leonardi-Bee; Wei Shen Lim; Abdullah Al Mamun; Ashish P. Anovadiya; Wildo N. Araújo; Eduardo Azziz-Baumgartner; Clarisa Báez; Carlos Bantar; Mazen M. Barhoush; Matteo Bassetti; Bojana Beovic; Roland Bingisser; Isabelle Bonmarin; Victor H. Borja-Aburto; Bin Cao; Jordi Carratala; María R. Cuezzo; Justin T. Denholm; Samuel R. Dominguez; Pericles A. D. Duarte; Gal Dubnov-Raz; Marcela Echavarria; Sergio Fanella; James M. Fraser; Zhancheng Gao; Patrick Gérardin; Maddalena Giannella; Sophie Gubbels; Jethro Herberg; Anjarath L. Higuera Iglesias; Peter H. Hoeger; Matthias Hoffmann; Xiaoyun Hu; Quazi T. Islam; Mirela F. Jiménez; Amr Kandeel; Gerben Keijzers; Hossein Khalili; Gulam Khandaker; Marian Knight; Gabriela Kusznierz; Ilija Kuzman; Arthur M. C. Kwan; Idriss Lahlou Amine; Eduard Langenegger; Kamran B. Lankarani; Yee-Sin Leo; Rita Linko; Pei Liu; Faris Madanat; Toshie Manabe; Elga Mayo-Montero; Allison Mcgeer; Ziad A. Memish; Gokhan Metan; Dragan Mikić; Kristin G. I. Mohn; Ahmadreza Moradi; Pagbajabyn Nymadawa; Bulent Ozbay; Mehpare Ozkan; Dhruv Parekh; Mical Paul; Wolfgang Poeppl; Fernando P. Polack; Barbara A. Rath; Alejandro H. Rodríguez; Marilda M. Siqueira; Joanna Skręt-Magierło; Ewa Talarek; Julian W. Tang; Antoni Torres; Selda H. Törün; Dat Tran; Timothy M. Uyeki; Annelies Van Zwol; Wendy Vaudry; Daiva Velyvyte; Tjasa Vidmar; Paul Zarogoulidis; Jonathan S. Nguyen-Van-Tam

doi:10.1111/irv.12363

Journal Articles Influenza and Other Respiratory Viruses Year : 2016

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

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Stella G. Muthuri

Function : Author

Sudhir Venkatesan

Function : Author

Puja R. Myles

Function : Author

Jo Leonardi-Bee

Function : Author

Wei Shen Lim

Function : Author

Abdullah Al Mamun

Function : Author

Ashish P. Anovadiya

Function : Author

Wildo N. Araújo

Function : Author

Eduardo Azziz-Baumgartner

Function : Author

Clarisa Báez

Function : Author

Carlos Bantar

Function : Author

Mazen M. Barhoush

Function : Author

Matteo Bassetti

Function : Author
PersonId : 981198

Ospedale "Santa Maria della Misericordia" = University Hospital "Santa Maria della Misericordia"

Bojana Beovic

Function : Author

Roland Bingisser

Function : Author

Isabelle Bonmarin

Function : Author

Institut de Veille Sanitaire

Victor H. Borja-Aburto

Function : Author

Bin Cao

Function : Author

Beijing Chao-Yang Hospital

Jordi Carratala

Function : Author

María R. Cuezzo

Function : Author

Justin T. Denholm

Function : Author

Samuel R. Dominguez

Function : Author

Pericles A. D. Duarte

Function : Author

Gal Dubnov-Raz

Function : Author

Marcela Echavarria

Function : Author

Sergio Fanella

Function : Author

James M. Fraser

Function : Author

Department of physics, engineering physics and astronomy

Zhancheng Gao

Function : Author

People's Hospital of Peking University

Patrick Gérardin

Function : Author
PersonId : 1289764
IdHAL : patrick-gerardin
ORCID : 0000-0002-3276-5919

Processus Infectieux en Milieu Insulaire Tropical

Maddalena Giannella

Function : Author

Sophie Gubbels

Function : Author

Jethro Herberg

Function : Author

Anjarath L. Higuera Iglesias

Function : Author

Peter H. Hoeger

Function : Author

Matthias Hoffmann

Function : Author

Xiaoyun Hu

Function : Author

Quazi T. Islam

Function : Author

Mirela F. Jiménez

Function : Author

Amr Kandeel

Function : Author

Gerben Keijzers

Function : Author
PersonId : 776961
ORCID : 0000-0003-1100-4552

Hossein Khalili

Function : Author

Gulam Khandaker

Function : Author

Marian Knight

Function : Author
PersonId : 918336

National Perinatal Epidemiology Unit

Gabriela Kusznierz

Function : Author

Instituto Nacional de Enfermedades Respiratorias Dr. Emilio Coni [Santa Fe, Argentina]

Ilija Kuzman

Function : Author

Arthur M. C. Kwan

Function : Author

Idriss Lahlou Amine

Function : Author

Eduard Langenegger

Function : Author

Kamran B. Lankarani

Function : Author

Yee-Sin Leo

Function : Author

Rita Linko

Function : Author

Pei Liu

Function : Author

State Key Laboratory of Advanced Electromagnetic Engineering and Technology

Faris Madanat

Function : Author

Toshie Manabe

Function : Author

Elga Mayo-Montero

Function : Author

Allison Mcgeer

Function : Author

Ziad A. Memish

Function : Author

Gokhan Metan

Function : Author

Dragan Mikić

Function : Author

Kristin G. I. Mohn

Function : Author

Ahmadreza Moradi

Function : Author

Pagbajabyn Nymadawa

Function : Author

Bulent Ozbay

Function : Author

Mehpare Ozkan

Function : Author

Dhruv Parekh

Function : Author

Mical Paul

Function : Author

Wolfgang Poeppl

Function : Author

Fernando P. Polack

Function : Author

Barbara A. Rath

Function : Author

Alejandro H. Rodríguez

Function : Author

Marilda M. Siqueira

Function : Author

Joanna Skręt-Magierło

Function : Author

Ewa Talarek

Function : Author

Julian W. Tang

Function : Author

Antoni Torres

Function : Author

Selda H. Törün

Function : Author

Dat Tran

Function : Author

Timothy M. Uyeki

Function : Author

Annelies Van Zwol

Function : Author

Wendy Vaudry

Function : Author

Daiva Velyvyte

Function : Author

Tjasa Vidmar

Function : Author

Paul Zarogoulidis

Function : Author

Jonathan S. Nguyen-Van-Tam

Function : Author

Abstract

Background The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. Results Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. Conclusions Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.

Keywords

Hospitalisation individual participant data meta-analyses influenza-related pneumonia neuraminidase inhibitors Open Access

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Life Sciences [q-bio]

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Submitted on : Thursday, June 28, 2018-11:05:27 AM

Last modification on : Wednesday, October 18, 2023-1:23:47 PM

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hal-01452880 , version 1 (28-06-2018)

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HAL Id : hal-01452880 , version 1
DOI : 10.1111/irv.12363

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Stella G. Muthuri, Sudhir Venkatesan, Puja R. Myles, Jo Leonardi-Bee, Wei Shen Lim, et al.. Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis. Influenza and Other Respiratory Viruses, 2016, 10 (3), pp.192--204. ⟨10.1111/irv.12363⟩. ⟨hal-01452880⟩

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Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

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