Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis - Archive ouverte HAL Access content directly
Journal Articles Influenza and Other Respiratory Viruses Year : 2016

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis

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Stella G. Muthuri
  • Function : Author
Sudhir Venkatesan
  • Function : Author
Puja R. Myles
  • Function : Author
Jo Leonardi-Bee
  • Function : Author
Wei Shen Lim
  • Function : Author
Abdullah Al Mamun
  • Function : Author
Ashish P. Anovadiya
  • Function : Author
Wildo N. Araújo
  • Function : Author
Eduardo Azziz-Baumgartner
  • Function : Author
Clarisa Báez
  • Function : Author
Carlos Bantar
  • Function : Author
Mazen M. Barhoush
  • Function : Author
Bojana Beovic
  • Function : Author
Roland Bingisser
  • Function : Author
Victor H. Borja-Aburto
  • Function : Author
Jordi Carratala
  • Function : Author
María R. Cuezzo
  • Function : Author
Justin T. Denholm
  • Function : Author
Samuel R. Dominguez
  • Function : Author
Pericles A. D. Duarte
  • Function : Author
Gal Dubnov-Raz
  • Function : Author
Marcela Echavarria
  • Function : Author
Sergio Fanella
  • Function : Author
Maddalena Giannella
  • Function : Author
Sophie Gubbels
  • Function : Author
Jethro Herberg
  • Function : Author
Anjarath L. Higuera Iglesias
  • Function : Author
Peter H. Hoeger
  • Function : Author
Matthias Hoffmann
  • Function : Author
Xiaoyun Hu
  • Function : Author
Quazi T. Islam
  • Function : Author
Mirela F. Jiménez
  • Function : Author
Amr Kandeel
  • Function : Author
Gerben Keijzers
Hossein Khalili
  • Function : Author
Gulam Khandaker
  • Function : Author
Marian Knight
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  • PersonId : 918336
Ilija Kuzman
  • Function : Author
Arthur M. C. Kwan
  • Function : Author
Idriss Lahlou Amine
  • Function : Author
Eduard Langenegger
  • Function : Author
Kamran B. Lankarani
  • Function : Author
Yee-Sin Leo
  • Function : Author
Rita Linko
  • Function : Author
Faris Madanat
  • Function : Author
Toshie Manabe
  • Function : Author
Elga Mayo-Montero
  • Function : Author
Allison Mcgeer
  • Function : Author
Ziad A. Memish
  • Function : Author
Gokhan Metan
  • Function : Author
Dragan Mikić
  • Function : Author
Kristin G. I. Mohn
  • Function : Author
Ahmadreza Moradi
  • Function : Author
Pagbajabyn Nymadawa
  • Function : Author
Bulent Ozbay
  • Function : Author
Mehpare Ozkan
  • Function : Author
Dhruv Parekh
  • Function : Author
Mical Paul
  • Function : Author
Wolfgang Poeppl
  • Function : Author
Fernando P. Polack
  • Function : Author
Barbara A. Rath
  • Function : Author
Alejandro H. Rodríguez
  • Function : Author
Marilda M. Siqueira
  • Function : Author
Joanna Skręt-Magierło
  • Function : Author
Ewa Talarek
  • Function : Author
Julian W. Tang
  • Function : Author
Antoni Torres
  • Function : Author
Selda H. Törün
  • Function : Author
Dat Tran
  • Function : Author
Timothy M. Uyeki
  • Function : Author
Annelies Van Zwol
  • Function : Author
Wendy Vaudry
  • Function : Author
Daiva Velyvyte
  • Function : Author
Tjasa Vidmar
  • Function : Author
Paul Zarogoulidis
  • Function : Author
Jonathan S. Nguyen-Van-Tam
  • Function : Author

Abstract

Background The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. Methods A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) ‘pandemic influenza’. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids. Results Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64–1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44–1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71–1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55–0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54–0·85; P = 0·001)]. Conclusions Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.
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hal-01452880 , version 1 (28-06-2018)

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Attribution - CC BY 4.0

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Stella G. Muthuri, Sudhir Venkatesan, Puja R. Myles, Jo Leonardi-Bee, Wei Shen Lim, et al.. Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis. Influenza and Other Respiratory Viruses, 2016, 10 (3), pp.192--204. ⟨10.1111/irv.12363⟩. ⟨hal-01452880⟩
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