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Comparative effects of corticotropin-releasing factor, arginine vasopressin, and related neuropeptides on the secretion of ACTH and α-MSH by frog anterior pituitary cells and neurointermediate lobes in vitro

Abstract : The ability of corticoliberin (CRF), urotensin I, sauvagine, arginine-vasopressin (AVP), and mesotocin to stimulate ACTH release by frog anterior pituitary cells and α-melanotropin (MSH) by frog neurointermediate lobe was studied in vitro using a perifusion technique. CRF and AVP were found to be potent stimulators of ACTH secretion, whereas urotensin I and sauvagine were totally inactive. In opposition to recent findings in the rat, CRF did not modify α-MSH secretion by the frog neurointermediate lobe. Mesotocin, which is present in the parenchymal cells of the frog pars intermedia, had no effect on α-MSH release in vitro. No potentiation of CRF-induced ACTH release was observed when anterior pituitary cells were incubated with a combination of AVP and CRF. Together with the recent elucidation of a CRF-like molecule in the frog diencephalon, these results suggest that, in Amphibia, CRF and AVP exert their stimulatory action specifically on distal lobe corticotrophs.
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https://hal.univ-reunion.fr/hal-01368989
Contributor : Gaël Potin <>
Submitted on : Tuesday, September 20, 2016 - 1:29:19 PM
Last modification on : Wednesday, August 7, 2019 - 12:09:34 PM

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Marie Christine Tonon, Pascale Cuet, Marek Lamacz, Sylvie Jégou, Jean Côté, et al.. Comparative effects of corticotropin-releasing factor, arginine vasopressin, and related neuropeptides on the secretion of ACTH and α-MSH by frog anterior pituitary cells and neurointermediate lobes in vitro. General and Comparative Endocrinology, Elsevier, 1986, 61 (3), ⟨10.1016/0016-6480(86)90231-5⟩. ⟨hal-01368989⟩

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