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Journal articles
High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar
Sarah Temmam
1, 2
Lydia Besnard
1
Soa F. Andriamandimby
3
Coralie Foray
1, 4
Harentsoaniaina Rasamoelina-Andriamanivo
5
Jean-Michel Heraud
6
Eric Cardinale
1, 4
Koussay Dellagi
1
Nicole Pavio
3
Hervé Pascalis
1
Vincent Porphyre
7
Sarah Temmam 1, 2
Author
Lydia Besnard 1
Author
Soa F. Andriamandimby 3
Author
Coralie Foray 1, 4
Author
Jean-Michel Heraud 6
Author IdHAL : jmheraud ResearcherId : http://www.researcherid.com/rid/O-1464-2013 ORCID : https://orcid.org/0000-0003-1107-0859
Eric Cardinale 1, 4
relator_rsp
Koussay Dellagi 1
Author
Nicole Pavio 3
Author
Hervé Pascalis 1
Author IdHAL : herve-pascalis ResearcherId : http://www.researcherid.com/rid/M-9410-2019 ORCID : https://orcid.org/0000-0002-6822-7311
Vincent Porphyre 7
Author
1
CRVOI - Centre de Recherche et de Veille sur les Maladies Émergentes dans l'Océan Indien (GIS-CRVOI
2, rue Maxime Rivière 97490 Sainte Clotilde La Réunion - Réunion)
- UR - Université de La Réunion (15, avenue René Cassin - CS92003 -97744 Saint Denis Cedex 9 - Réunion)
2
LEM - Laboratoire d'Ecologie Microbienne - UMR 5557 (BAT GREGOR MENDEL (ex 741)-4 et 43 Bvd du 11 Novembre 1918 69622 VILLEURBANNE CEDEX - France)
- INRA - Institut National de la Recherche Agronomique : UMR1418 (France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5557 (France)
- VAS - VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique) - France)
- ENVL - Ecole Nationale Vétérinaire de Lyon (France)
3
Institut Pasteur de Madagascar (B.P. 1274 Antananarivo - Madagascar)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
4
UMR CMAEE - Contrôle des maladies animales exotiques et émergentes (Campus international de Baillarguet - TA A-15 / G - 34398 Montpellier Cedex 5 ou Domaine Duclos - Prise-D'eau - 97170 Petit-Bourg Guadeloupe ou CRVOI - BP 80005 - 2 rue Maxime Rivière - 97491 Sainte-Clotilde Cedex Réunion ou ISRA/LNERV - Route du Front de Terre - BP 2057 - Dakar Hann Sénégal - France)
- Cirad - Centre de Coopération Internationale en Recherche Agronomique pour le Développement : UMR15 (Siège 42, rue Scheffer 75116 Paris - France)
- INRA - Institut National de la Recherche Agronomique : UMR1309 (France)
5
Département de Recherches Zootechniques et Vétérinaires, (Antananarivo - Madagascar)
- FOFIFA - Centre National de Recherche Appliquée au Développement Rural (CENRADERU Antananarivo - Madagascar)
6
IPM - Unité de Virologie [Antananarivo, Madagascar] (Antananarivo, Madagascar - Madagascar)
- Institut Pasteur de Madagascar (B.P. 1274 Antananarivo - Madagascar)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
7
Cirad - Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Siège 42, rue Scheffer 75116 Paris - France)
Abstract : Hepatitis E virus (HEV) causes an orofecal disease transmitted through poor hygiene environments, contaminated food (mainly pork products), or by contacts with infected animals. Very little data are currently available regarding the disease in the Southwestern Indian Ocean Islands. We report the first sero- and viro-survey for HEV in human and swine in Madagascar. A seroprevalence rate of 14.1% (60 of 427) was measured in slaughterhouse workers. Seroprevalence to HEV in pigs was estimated to 71.2% (178 of 250), strongly suggesting the existence of a zoonotic cycle. Three out of 250 pig livers (1.2%) tested HEV RNA-positive by quantitative polymerase chain reaction. Phylogenetic analyses based on 1-kb sequences of the ORF 2-3 identified these viruses as HEV genotype 3. Sequences clustered in a distinct Malagasy sub-clade, possibly representative of a new sub-genotype, for which the date of emergence was estimated around 1989. Further studies are needed to confirm other transmission routes of HEV to humans, especially through non-zoonotic cycles.
Document type :
Journal articles
Complete list of metadata
https://hal.univ-reunion.fr/hal-01274574
Contributor : Réunion Univ <>
Submitted on : Tuesday, February 16, 2016 - 8:41:17 AM
Last modification on : Friday, July 9, 2021 - 3:48:08 PM
Contributor : Réunion Univ <>
Submitted on : Tuesday, February 16, 2016 - 8:41:17 AM
Last modification on : Friday, July 9, 2021 - 3:48:08 PM
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Identifiers
- HAL Id : hal-01274574, version 1
- PUBMED : 23208879
- DOI : 10.4269/ajtmh.2012.12-0615
- PUBMEDCENTRAL : PMC3583326
Collections
PIMIT | UNIV-REUNION | INRA | RIIP | RIIP_MADAGASCAR | CIRAD | AGROPOLIS | PAPANGUE | INRAE | UNIV-LYON1 | BIOENVIS | CNRS | UDL | ECOMIC | AFRIQ
Citation
Sarah Temmam, Lydia Besnard, Soa F. Andriamandimby, Coralie Foray, Harentsoaniaina Rasamoelina-Andriamanivo, et al.. High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 88 (2), pp.329--338. ⟨10.4269/ajtmh.2012.12-0615⟩. ⟨hal-01274574⟩
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