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Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection

Duksha Ramful 1, 2, 3 Sylvain Samperiz 1 Xavier Fritel 4, 1, 5 Alain Michault 6, 1 Marie-Christine Jaffar-Bandjee 7, 1, 3 Olivier Rollot 2, 1 Brahim Boumahni 1 Patrick Gérardin 8, 2, 1
1 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
2 CIC-EC - CIC régional épidémiologie clinique/essais cliniques - Ile de la Réunion
3 GRI - Groupe de Recherche en Immunopathologies et maladies infectueuses
4 Service de gynécologie et obstétrique [Poitiers]
5 Inserm U1018, CIC0802
Service de gynécologie et obstétrique [Poitiers], CESP - Centre de recherche en épidémiologie et santé des populations, Université de Poitiers - Faculté de Médecine et de Pharmacie, CIC - Poitiers
6 Laboratoire de Bactériologie-Parasitologie-Virologie-Hygiène
7 Microbiology Laboratory
8 Réanimation médicale néonatale et pédiatrique
Abstract : To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.
Keywords : Infant Newborn Infectious Disease Transmission Adult Alphavirus Infections Antibodies Viral Chikungunya virus Female Humans Immunoglobulin G Immunoglobulin M Vertical Pregnancy Pregnancy Complications Infectious
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https://hal.univ-reunion.fr/hal-01274572
Contributor : Réunion Univ <>
Submitted on : Tuesday, February 16, 2016 - 8:41:07 AM
Last modification on : Wednesday, September 16, 2020 - 5:45:32 PM

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Duksha Ramful, Sylvain Samperiz, Xavier Fritel, Alain Michault, Marie-Christine Jaffar-Bandjee, et al.. Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection. Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 209 (11), pp.1726--1730. ⟨10.1093/infdis/jit814⟩. ⟨hal-01274572⟩

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