Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis - Archive ouverte HAL Access content directly
Journal Articles Journal of Maternal-Fetal & Neonatal Medicine Year : 2013

Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis

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Xavier Carbonell-Estrany
  • Function : Author
  • PersonId : 905734
John R. Fullarton
  • Function : Author
Katherine L. Gooch
  • Function : Author
Pamela G. Vo
  • Function : Author
Jose Figueras-Aloy
  • Function : Author
Marcello Lanari
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Johannes G. Liese
  • Function : Author

Abstract

OBJECTIVE: To assess the impact of household smoking and palivizumab prophylaxis on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm (32-35 weeks' gestational age) infants. METHODS: Familial smoking and other RSV risk factor data from the FLIP, FLIP-2 and IMpact studies and datasets from France, Germany and Italy, together with palivizumab prophylaxis data from the FLIP-2 and IMpact studies, were analysed using cross-correlation and Bayesian meta-analytical modelling employing Markov Chain Monte Carlo sampling. RESULTS: There were 2.35 times (95% confidence interval [CI] 1.37-4.02) as many hospitalisations amongst infants from smoking compared with those from non-smoking families. Among non-prophylaxed infants, there were 2.53 times (95% CI 1.27-4.94) as many RSV hospitalisations from smoking than from non-smoking families and that excess hospitalisation was reduced to 1.03 times (95% CI 0.38-2.99) amongst prophylaxed infants. Familial smoking correlates significantly (p \textless 0.01) with other RSV risk factors: positive correlation with number of school-age siblings, history of family atopy, family wheeze and gestational age; negative correlation with birth weight and breast feeding. CONCLUSIONS: Late-preterm infants from smoking families appear to be at heightened risk for severe RSV infection requiring hospitalisation of which the risk may be reduced with RSV prophylaxis.
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hal-01194208 , version 1 (05-09-2015)

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Xavier Carbonell-Estrany, John R. Fullarton, Katherine L. Gooch, Pamela G. Vo, Jose Figueras-Aloy, et al.. Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis. Journal of Maternal-Fetal & Neonatal Medicine, 2013, 26 (9), pp.926--931. ⟨10.3109/14767058.2013.765850⟩. ⟨hal-01194208⟩
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