AOM azoxymethane APC APC regulator of WNT signaling pathway ATG autophagy related Atg16l1[∆MC] mice mice deficient for Atg16l1 specifically in myeloid cells CASP1 caspase 1 BMDM bone marrow-derived macrophage CFU colony-forming unit CoPEC colibactin-producing Escherichia coli CRC colorectal cancer CXCL1/KC C-X-C motif chemokine ligand 1 ELISA enzyme-linked immunosorbent assay IL interleukin MC myeloid cell MOI multiplicity of infection PBS phosphatebuffered saline pks polyketide synthase qRT-PCR quantitative real-time reverse-transcription polymerase chain reaction siRNA small interfering RNA TME tumor microenvironment TNF/TNF-α tumor necrosis factor Autophagy bacterial infection colibactinproducing E. coli colorectal cancer toxin azoxymethane APC APC regulator of WNT signaling pathway ATG autophagy related Atg16l1[∆MC] mice mice deficient for Atg16l1 specifically in myeloid cells CASP1 caspase 1 BMDM bone marrow-derived macrophage CFU colony-forming unit CoPEC colibactin-producing Escherichia coli CRC colorectal cancer CXCL1/KC C-X-C motif chemokine ligand 1 ELISA enzyme-linked immunosorbent assay IL interleukin MC myeloid cell MOI multiplicity of infection PBS phosphatebuffered saline pks polyketide synthase qRT-PCR quantitative real-time reverse-transcription polymerase chain reaction siRNA small interfering RNA TME tumor microenvironment TNF/TNF-α tumor necrosis factor Autophagy bacterial infection colibactinproducing E. coli toxin