Blood transfusion of the donor is associated with stage 3 primary graft dysfunction after lung transplantation - Université de La Réunion Accéder directement au contenu
Article Dans Une Revue Clinical Transplantation Année : 2021

Blood transfusion of the donor is associated with stage 3 primary graft dysfunction after lung transplantation

Résumé

Background The first aim of this study was to assess the association between stage 3 PGD and pre‐donation blood transfusion of the donor. The secondary objectives were to assess the epidemiology of donor transfusion and the outcome of LT recipients according to donor transfusion status and massive donor transfusion status. Methods This was an observational, prospective, single‐center study. The results are expressed as absolute numbers, percentages, medians, and interquartile ranges. Statistical analyses were performed using Chi squared, Fischer's exact tests, and Mann‐Whitney U tests ( P < .05 was considered significant). A multivariate analysis was performed. Results Between January 2016 and February 2019, 147 patients were included in the analysis. PGD was observed in 79 (54%) patients, 45 (31%) of whom had stage 3 PGD. Pre‐donation blood transfusion was administered in 48 (33%) donors (median of 3[1–9] packed red cells (PRCs)). On multivariate analysis, stage 3 PGD was significantly associated with donor blood transfusion (OR 2.69, IC (1.14–6.38), P = .024). Mortality at days 28 and 90 was not significantly different according to the pre‐donation transfusion status of the donor. Conclusion Pre‐donation blood transfusion is associated with stage 3 PGD occurrence after LT. Transfusion data of the donor should be included in donor lung assessment.
Fichier non déposé

Dates et versions

hal-04540177 , version 1 (10-04-2024)

Identifiants

Citer

Yoann Elmaleh, Christian de Tymowski, Nathalie Zappella, Sylvain Jean-Baptiste, Alexy Tran-Dinh, et al.. Blood transfusion of the donor is associated with stage 3 primary graft dysfunction after lung transplantation. Clinical Transplantation, 2021, 35 (9), ⟨10.1111/ctr.14407⟩. ⟨hal-04540177⟩
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More