Skip to Main content Skip to Navigation
Journal articles

Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract

Abstract : Overweight and obesity are worldwide health concerns leading to many physiological disorders. Recent data highlighted their deleterious effects on brain homeostasis and plasticity, but the mechanisms underlying such disruptions are still not well understood. In this study, we developed and characterized a fast and reliable diet-induced overweight (DIO) model in zebrafish, for (1) studying the effects of overfeeding on brain homeostasis and for (2) testing different preventive and/or therapeutic strategies. By overfeeding zebrafish for 4 weeks, we report the disruption of many metabolic parameters reproducing human overweight features including increased body weight, body mass index, fasting blood glucose levels and liver steatosis. Furthermore, DIO fish displayed blood–brain barrier leakage, cerebral oxidative stress, neuroinflammation and decreased neurogenesis. Finally, we investigated the preventive beneficial effects of A. borbonica, an endogenous plant from Reunion Island. Overnight treatment with A. borbonica aqueous extract during the 4 weeks of overfeeding limited some detrimental central effects of DIO. In conclusion, we established a relevant DIO model in zebrafish demonstrating that overfeeding impairs peripheral and central homeostasis. This work also highlights the preventive protective effects of A. borbonica aqueous extracts in DIO, and opens a way to easily screen drugs aiming at limiting overweight and associated neurological disorders.
Document type :
Journal articles
Complete list of metadatas

Cited literature [86 references]  Display  Hide  Download

https://hal.univ-reunion.fr/hal-02933261
Contributor : Réunion Univ <>
Submitted on : Tuesday, September 8, 2020 - 11:52:07 AM
Last modification on : Thursday, September 10, 2020 - 3:25:06 AM

File

s41598-020-71402-2.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Batoul Ghaddar, Bryan Veeren, Philippe Rondeau, Matthieu Bringart, Christian Lefebvre d'Hellencourt, et al.. Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract. Scientific Reports, Nature Publishing Group, 2020, pp.14496. ⟨10.1038/s41598-020-71402-2⟩. ⟨hal-02933261⟩

Share

Metrics

Record views

11

Files downloads

20