A. M. Abdel-azeem, A. , M. A. Darwish, A. G. Nafady, N. A. Ibrahim et al., Fusarium: biodiversity, ecological significances, and industrial applications, Recent advancement in white biotechnology through fungi, vol.1, pp.201-261, 2019.

L. Alcazar-fuoli, E. Mellado, G. Garcia-effron, J. F. Lopez, J. O. Grimalt et al., Ergosterol biosynthesis pathway in Aspergillus fumigatus, Steroids, vol.73, pp.339-347, 2008.

B. Arndt, L. Studt, P. Wiemann, H. Osmanov, K. Kleigrewe et al., Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi, Fungal Genet Biol, vol.84, pp.26-36, 2015.

J. Avalos, E. Cerdá-olmedo, F. Reyes, and A. F. Barrero, Gibberellins and other metabolites of Fusarium fujikuroi and related fungi, Curr Org Chem, vol.11, pp.721-737, 2007.

J. Avalos, J. Pardo-medina, O. Parra-rivero, M. Ruger-herreros, R. Rodríguez-ortiz et al., Carotenoid biosynthesis in Fusarium. J Fungi, vol.3, p.39, 2017.

C. W. Bacon, J. K. Porter, W. P. Norred, and J. F. Leslie, Production of fusaric acid by Fusarium species, Appl Environ Microbiol, vol.62, pp.4039-4043, 1996.

J. Balan, J. Fuska, I. Kuhr, and V. Kuhrová, Bikaverin, an antibiotic from Gibberella fujikuroi, effective against Leishmania brasiliensis, Folia Microbiol, vol.15, pp.479-484, 1970.

A. Bekaert, J. Andrieux, and M. Plat, New total synthesis of bikaverin, Tetrahedron Lett, vol.33, issue.00, pp.78863-78863, 1992.

A. A. Bell, M. H. Wheeler, J. Liu, R. D. Stipanovic, L. S. Puckhaber et al., United States Department of Agriculture-Agricultural Research Service studies on polyketide toxins of Fusarium oxysporum f sp vasinfectum: potential targets for disease control, Pest Manag Sci, vol.59, pp.736-747, 2003.

J. L. Bicas and W. S. Silva, Process of production and deriving pigment application of the fungus Fusarium oxysporum, p.102013015305, 2013.

D. Brewer, G. P. Arsenault, J. Wright, and L. C. Vining, Production of bikaverin by Fusarium oxysporum and its identity with lycopersin, J Antibiot, vol.26, pp.778-781, 1973.

D. W. Brown, R. A. Butchko, S. E. Baker, and R. H. Proctor, Phylogenomic and functional domain analysis of polyketide synthases in Fusarium, Fungal Biol, vol.116, pp.318-331, 2012.

J. D. Bu'lock, R. W. Detroy, Z. Ho??álek, and A. Munim-al-shakarchi, Regulation of secondary biosynthesis in Gibberella fujikuroi, Trans Br Mycol Soc, vol.62, issue.74, p.80046, 1974.

Y. Caro, M. Venkatachalam, J. Lebeau, M. Fouillaud, and L. Dufossé, Pigments and colorants from filamentous fungi, Fungal metabolites. Reference Series in Phytochemistry, pp.499-568, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01444915

R. Caspi, R. Billington, C. A. Fulcher, I. M. Keseler, A. Kothari et al., The MetaCyc database of metabolic pathways and enzymes, Nucleic Acids Res, vol.46, pp.633-639, 2018.

J. Chelkowski, P. Zajkowski, and A. Visconti, Bikaverin production by Fusarium species, Mycotoxin Res, vol.8, pp.73-76, 1992.

A. Combès, I. Ndoye, C. Bance, J. Bruzaud, C. Djediat et al., Chemical communication between the endophytic fungus Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum, PLoS ONE, vol.7, 2012.

C. Cortinovis, F. Pizzo, L. J. Spicer, and F. Caloni, Fusarium mycotoxins: effects on reproductive function in domestic animals-a review, Theriogenology, vol.80, pp.557-564, 2013.

M. E. Da-silva-ferreira, A. L. Colombo, I. Paulsen, Q. Ren, J. Wortman et al., The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus, Med Mycol, vol.43, pp.313-319, 2005.

Z. T. Dame, B. Silima, M. Gryzenhout, and T. Van-ree, Bioactive compounds from the endophytic fungus Fusarium proliferatum, Nat Prod Res, vol.30, p.89, 2016.

D. Mauro, E. Xu, R. Soliveri, G. Santato, and C. , Natural melanin pigments and their interfaces with metal ions and oxides: emerging concepts and technologies, MRS Commun, vol.7, pp.141-151, 2017.

V. Díaz-sánchez, J. Avalos, and M. C. Limón, Identification and regulation of fusA, the polyketide synthase gene responsible for fusarin production in Fusarium fujikuroi, Appl Environ Microbiol, vol.78, pp.7258-7266, 2012.

L. Dufossé, M. Fouillaud, Y. Caro, S. Mapari, and N. Sutthiwong, Filamentous fungi are large-scale producers of pigments and colorants for the food industry, Curr Opin Biotechnol, vol.26, pp.56-61, 2014.

S. Dupont, G. Lemetais, T. Ferreira, P. Cayot, P. Gervais et al., , vol.66, pp.2961-2968, 2012.

E. Escamilla-silva, H. Poggi-varaldo, M. M. De-la-torre-martínez, S. Cornejo, M. Dendooven et al., Selective production of bikaverin in a fluidized bioreactor with immobilized Gibberella fujikuroi, World J Microbiol Biotechnol, vol.17, pp.469-474, 2001.

L. Escrivá, G. Font, and L. Manyes, vivo toxicity studies of fusarium mycotoxins in the last decade: a review, vol.78, pp.185-206, 2015.

N. Fangkrathok, B. Sripanidkulchai, K. Umehara, and H. Noguchi, Bioactive ergostanoids and a new polyhydroxyoctane from Lentinus polychrous mycelia and their inhibitory effects on E2-enhanced cell proliferation of T47D cells, Nat Prod Res, vol.27, p.9, 2013.

J. Fotso, J. F. Leslie, and J. S. Smith, Production of beauvericin, moniliformin, fusaproliferin, and fumonisins b(1), b(2), and b(3) by fifteen ex-type strains of Fusarium species, Appl Environ Microbiol, vol.68, pp.5195-5197, 2002.

M. Fouillaud, M. Venkatachalam, E. Girard-valenciennes, Y. Caro, and L. Dufossé, Anthraquinones and derivatives from marine-derived fungi: structural diversity and selected biological activities, Mar Drugs, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01399825

R. Frandsen, N. J. Nielsen, N. Maolanon, J. C. Sørensen, S. Olsson et al., The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones, Mol Microbiol, vol.61, pp.1069-1080, 2006.

I. Gaffoor and F. Trail, Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae, Appl Environ Microbiol, vol.72, pp.1793-1799, 2006.

I. Garbayo, C. V??chez, J. Nava-saucedo, and J. Barbotin, Nitrogen, carbon and light-mediated regulation studies of carotenoid biosynthesis in immobilized mycelia of Gibberella fujikuroi, Enzyme Microb Technol, vol.33, pp.629-634, 2003.

W. Giordano, J. Avalos, E. Cerdá-olmedo, and C. E. Domenech, Nitrogen availability and production of bikaverin and gibberellins in Gibberella fujikuroi, FEMS Microbiol Lett, vol.173, issue.99, pp.106-114, 1999.

R. Gmoser, J. A. Ferreira, P. R. Lennartsson, and M. J. Taherzadeh, Filamentous ascomycetes fungi as a source of natural pigments, Fungal Biol Biotechnol, vol.4, 2017.

S. Haidar, Z. Bouaziz, C. Marminon, T. Laitinen, A. Poso et al., Development of pharmacophore model for indeno[1,2-b]indoles as human protein kinase CK2 inhibitors and database mining, Pharmaceuticals, vol.10, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02480388

S. Haidar, D. Aichele, R. Birus, J. Hielscher, T. Laitinen et al., In vitro and in silico evaluation of bikaverin as a potent inhibitor of human protein kinase CK2, Molecules, vol.24, p.1380, 2019.

F. T. Hansen, J. L. Sørensen, T. E. Sondergaard, H. Giese, and R. Frandsen, Quick guide to secondary metabolite genes in Fusarium, Int J Food Microbiol, vol.155, pp.128-136, 2012.

J. F. Henderson, M. L. Battell, G. Zombor, J. Fuska, and P. Nemec, Effects of bikaverin on purine nucleotide synthesis and catabolism in Ehrlich ascites tumor cells in vitro, Biochem Pharmacol, vol.26, pp.1973-1977, 1977.

J. E. Kim, K. H. Han, J. J. Kim, H. Kim, J. C. Yun et al., Putative polyketide synthase and laccase genes for biosynthesis of aurofusarin in Gibberella zeae, Appl Environ Microbiol, vol.71, pp.1701-1708, 2005.

H. Kim, G. Choi, H. Lee, S. Lee, H. Lim et al., Some fungal endophytes from vegetable crops and their anti-oomycete activities against tomato late blight, Lett Appl Microbiol, vol.44, pp.332-337, 2007.

M. Klaus and M. Grininger, Engineering strategies for rational polyketide synthase design, Nat Prod Rep, vol.35, pp.1070-1081, 2018.

A. Klitgaard, A. Iversen, M. R. Andersen, T. O. Larsen, J. C. Frisvad et al., Aggressive dereplication using UHPLC-DAD-QTOF: screening extracts for up to 3000 fungal secondary métabolites, Anal Bioanal Chem, vol.406, pp.1933-1943, 2014.

J. Koizumi, N. Takatani, N. Kobayashi, K. Mikami, K. Miyashita et al., Carotenoid profiling of a red seaweed Pyropia yezoensis: insights into biosynthetic pathways in the order Bangiales, Mar Drugs, vol.16, p.426, 2018.

H. Kwon, S. Son, H. Han, G. Choi, K. Jang et al., Nematicidal activity of bikaverin and fusaric acid isolated from Fusarium oxysporum against pine wood nematode, Bursaphelenchus xylophilus, Plant Pathol J, vol.23, pp.318-321, 2007.

G. J. Lale and R. V. Gadre, Production of bikaverin by a Fusarium fujikuroi mutant in submerged cultures, AMB Express, vol.6, p.34, 2016.

J. Lebeau, M. Venkatachalam, M. Fouillaud, T. Petit, F. Vinale et al., Production and new extraction method of polyketide red pigments produced by ascomycetous fungi from terrestrial and marine habitats, J Fungi, vol.3, p.34, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01599694

J. Lebeau, T. Petit, P. Clerc, L. Dufossé, and Y. Caro, Isolation of two novel purple naphthoquinone pigments concomitant with the bioactive red bikaverin and derivates thereof produced by Fusarium oxysporum, Biotechnol Prog, vol.35, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02562093

M. C. Limón, R. Rodríguez-ortiz, and J. Avalos, Bikaverin production and applications, Appl Microbiol Biotechnol, vol.87, pp.21-29, 2010.

P. Linnemannstöns, J. Schulte, M. Del-mar-prado, R. H. Proctor, J. Avalos et al., The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin, Fungal Genet Biol, vol.37, pp.134-148, 2002.

V. C. Liuzzi, V. Mirabelli, M. T. Cimmarusti, M. Haidukowski, J. F. Leslie et al., Enniatin and beauvericin biosynthesis in Fusarium species: production profiles and structural determinant prediction, Toxins, vol.9, p.45, 2017.

A. Logrieco, A. Moretti, G. Castella, M. Kostecki, P. Golinski et al., Beauvericin production by Fusarium species, Appl Environ Microbiol, vol.64, pp.3084-3088, 1998.

E. Lysøe, S. S. Klemsdal, K. R. Bone, R. Frandsen, T. Johansen et al., The PKS4 gene of Fusarium graminearum is essential for zearalenone production, Appl Environ Microbiol, vol.72, pp.3924-3932, 2006.

S. M. Ma, J. Zhan, K. Watanabe, X. Xie, W. Zhang et al., Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi, J Am Chem Soc, vol.129, pp.10642-10643, 2007.

L. J. Ma, H. C. Van-der-does, K. A. Borkovich, J. J. Coleman, M. J. Daboussi et al., Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium oxysporum, Nature, vol.464, pp.367-373, 2010.

L. J. Ma, D. M. Geiser, R. H. Proctor, A. P. Rooney, O. Donnell et al., Fusarium pathogenomics, Annu Rev Microbiol, vol.67, pp.399-416, 2013.

S. Mapari, M. E. Hansen, A. S. Meyer, and U. Thrane, Computerized screening for novel producers of Monascus-like food pigments in Penicillium species, J Agric Food Chem, vol.56, pp.9981-9989, 2008.

K. A. Markham, C. M. Palmer, M. Chwatko, J. M. Wagner, C. Murray et al., Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation, Alper HS, vol.115, pp.2096-2101, 2018.

I. Marova, M. Carnecka, A. Halienova, E. Breierova, and R. Koci, Yeast biomass supplemented with carotenoids/ergosterol, Food Technol Biotechnol, vol.48, pp.56-61, 2010.

A. G. Medentsev, A. Y. Arinbasarova, and V. K. Akimenko, Biosynthesis of naphthoquinone pigments by fungi of the genus Fusarium, Appl Biochem Microbiol, vol.41, pp.503-507, 2005.

A. B. Mostert, B. J. Powell, F. L. Pratt, G. R. Hanson, T. Sarna et al., Role of semiconductivity and ion transport in the electrical conduction of melanin, PNAS, vol.109, pp.8943-8947, 2012.

F. Nazari, M. Sulyok, F. Kobarfard, H. Yazdanpanah, and R. Krska, Evaluation of emerging Fusarium mycotoxins beauvericin, enniatins, fusaproliferin and moniliformin in domestic rice in iran, Iran J Pharm Res, vol.14, pp.505-512, 2015.

E. Niehaus, V. Bargen, K. W. Espino, J. J. Pfannmüller, A. Humpf et al., Characterization of the fusaric acid gene cluster in Fusarium fujikuroi, Appl Microbiol Biotechnol, vol.98, pp.1749-1762, 2014.

E. Niehaus, L. Studt, K. W. Von-bargen, W. Kummer, H. Humpf et al., Sound of silence: the beauvericin cluster in Fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification, Environ Microbiol, vol.18, pp.4282-4302, 2016.

K. F. Nielsen and J. Smedsgaard, Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology, J Chromatogr A, vol.1002, pp.111-136, 2003.

D. Nirmaladevi, M. Venkataramana, S. Chandranayaka, A. Ramesha, N. M. Jameel et al., Neuroprotective effects of bikaverin on H 2 O 2 -induced oxidative stress mediated neuronal damage in SH-SY5Y cell line, Cell Mol Neurobiol, vol.34, pp.973-985, 2014.

W. P. Norred, R. D. Plattner, R. F. Vesonder, C. W. Bacon, K. Voss et al., Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes, Appl Microbiol Biotechnol, vol.30, pp.3493-3511, 1992.

R. H. Proctor, R. Butchko, D. W. Brown, and A. Moretti, Functional characterization, sequence comparisons and distribution of a polyketide synthase gene required for perithecial pigmentation in some Fusarium species, Food Addit Contam, vol.24, pp.1076-1087, 2007.

R. H. Proctor, M. Busman, J. A. Seo, Y. W. Lee, and R. D. Plattner, A fumonisin biosynthetic gene cluster in Fusarium oxysporum strain O-1890 and the genetic basis for B versus C fumonisin production, Fungal Genet Biol, vol.45, pp.1016-1026, 2008.

C. Ramesh, N. V. Vinithkumar, R. Kirubagaran, C. K. Venil, and L. Dufossé, Multifaceted applications of microbial pigments: current knowledge, challenges and future directions for public health implications, vol.7, p.186, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02563390

R. Rodríguez-ortiz, B. J. Mehta, J. Avalos, and M. C. Limón, Stimulation of bikaverin production by sucrose and by salt starvation in Fusarium fujikuroi, Appl Microbiol Biotechnol, vol.85, 1991.

J. Schumacher, A. Gautier, G. Morgant, L. Studt, P. H. Ducrot et al., A functional bikaverin biosynthesis gene cluster in rare strains of Botrytis cinerea is positively controlled by VELVET, PLoS ONE, vol.8, p.29, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01190541

A. Slominski, I. Semak, J. Zjawiony, J. Wortsman, M. N. Gandy et al., Enzymatic metabolism of ergosterol by cytochrome p450scc to biologically active 17alpha,24-dihydroxyergosterol, Chem Biol, vol.12, pp.931-939, 2005.

S. W. Son, H. Y. Kim, G. J. Choi, H. K. Lim, K. S. Jang et al., Bikaverin and fusaric acid from Fusarium oxysporum show antioomycete activity agains Phytophtora infestans, J Appl Microbiol, vol.104, pp.692-698, 2008.

Z. Song, R. J. Cox, C. M. Lazarus, and T. J. Simpson, Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum, vol.5, pp.1196-1203, 2004.

J. L. Sørensen, K. F. Nielsen, and T. E. Sondergaard, Redirection of pigment biosynthesis to isocoumarins in Fusarium, Fungal Genet Biol, vol.49, pp.613-618, 2012.

E. Stanisz, A. Zgo?a-grze?kowiak, A. Wa?kiewicz, L. St?pie?, and M. Beszterda, Can ergosterol be an indicator of Fusarium fungi and mycotoxins in cereal products?, J Braz Chem Soc, vol.26, p.30, 2015.

L. Studt, P. Wiemann, K. Kleigrewe, H. U. Humpf, and B. Tudzynski, Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia, Appl Environ Microbiol, vol.78, pp.4468-4480, 2012.

N. Sutthiwong, Y. Caro, P. Laurent, M. Fouillaud, and L. Dufossé, Production of biocolours, Biotechnology in agriculture and food processing: opportunities and challenges, pp.419-437, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01188115

J. H. Tatum, R. A. Baker, and R. E. Berry, Three further naphthoquinones produced by Fusarium solani, Phytochemistry, vol.24, pp.3019-3021, 1985.

S. Torres, D. Cajas, G. Palfner, A. Astuya, A. Aballay et al., Steroidal composition and cytotoxic activity from fruiting body of Cortinarius xiphidipus, Nat Prod Res, vol.31, pp.473-476, 2017.

P. Velmurugan, S. Kamala-kannan, V. Balachandar, P. Lakshmanaperumalsamy, J. C. Chae et al., Natural pigment extraction from five filamentous fungi for industrial applications and dyeing of leather, Carbohydr Polym, vol.79, pp.261-268, 2010.

Q. Wang and L. Xu, Beauvericin, a bioactive compound produced by fungi: a short review, Molecules, vol.17, pp.2367-2377, 2012.

L. A. Wiebe and L. F. Bjeldanes, Fusarin C, a mutagen from Fusarium moniliforme grown on corn, J Food Sci, vol.46, pp.1424-1426, 1981.

P. Wiemann, A. Willmann, M. Straeten, K. Kleigrewe, M. Beyer et al., Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation, Mol Microbiol, vol.72, pp.931-946, 2009.

Q. Wu, J. Patocka, E. Nepovimova, and K. Kuca, A review on the synthesis and bioactivity aspects of beauvericin, a Fusarium mycotoxin, Front Pharmacol, vol.9, p.1338, 2018.

J. Zhan, A. M. Burns, M. X. Liu, S. H. Faeth, and A. A. Gunatilaka, Search for cell mobility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum, J Nat Prod, vol.70, pp.227-232, 2007.

J. Zhao, W. Lin, X. Ma, Q. Lu, X. Ma et al., The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae, Genomics, vol.95, pp.290-298, 2010.

, Publisher's Note

, Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations