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Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia

Abstract : There are 3 isoforms of apolipoprotein E (apo E) in humans (ε2, ε3, and ε4). They differ by single amino acid substitutions that variably affect their affinity for the low-density lipoprotein receptor (LDLR) and for the LDLR-related protein (LRP1), with ε2 having the weakest binding to these receptors (1). The plasma levels of lipoprotein(a) [Lp(a)], a highly atherogenic LDL-like lipoprotein species, are influenced by the polymorphism of apo E, with ε2/ε2 and ε4/ε4 carriers presenting with the lowest and highest Lp(a) plasma concentrations, respectively (1).
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Valentin Blanchard, Mikael Croyal, Ilya Khantalin, Stéphane Ramin-Mangata, Kévin Chemello, et al.. Reduced Lipoprotein(a) Associated With the Apolipoprotein E2 Genotype Confers Cardiovascular Protection in Familial Hypercholesterolemia. JACC : Basic to Translational Science, Elsevier on behalf of the American College of Cardiology Foundation, 2019, 4 (3), pp.425-427. ⟨10.1016/j.jacbts.2019.03.002⟩. ⟨hal-02429499⟩

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