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Journal articles
TP53 drives invasion through expression of its Δ133p53β variant
Gilles Gadéa
1
Nikola Arsic
2
Kenneth Fernandes
3
Alexandra Diot
4
Sébastien Joruiz
5
Samer Abdallah
1
Valerie Meuray
4
Stéphanie Vinot
1
Christelle Anguille
1
Judit Remenyi
5
Marie Khoury
6
Philip Quinlan
7
Colin Purdie
8
Lee Jordan
9
Frances Fuller-Pace
5
Marion de Toledo
1
Maïlys Cren
10
Alastair Thompson
11
Jean-Christophe Bourdon
4
Pierre Roux
12
Christelle Anguille 1
Author
Judit Remenyi 5
Author
Marie P. Khoury 6
Author
Philip Quinlan 7
Author
Colin Purdie 8
Author
Lee Jordan 9
Author
Frances Fuller-Pace 5
Author
Marion de Toledo 1
Author IdHAL : marion-de-toledo ORCID : https://orcid.org/0000-0002-7638-0041
Maïlys Cren 10
Author
Alastair Thompson 11
Author
Jean-Christophe Bourdon 4
Author
Pierre Roux 12
Author
1
CRBM - Centre de recherche en Biologie Cellulaire (1919 Route de Mende 34293 MONTPELLIER CEDEX 5 - France)
- UM2 - Université Montpellier 2 - Sciences et Techniques (Place Eugène Bataillon - 34095 Montpellier cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5237 (France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
2
IGMM - Institut de Génétique Moléculaire de Montpellier (1919 Route de Mende - 34293 Montpellier Cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5535 (France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
3
Centre for Oncology and Molecular Medicine (Dundee, DD1 9SY - United Kingdom)
- University of Dundee (University of Dundee Nethergate Dundee Scotland, UK DD1 4HN - United Kingdom)
- INSERM - Institut National de la Santé et de la Recherche Médicale : INSERM : LABORATOIRE EUROPEEN ASSOCIÉ (101, rue de Tolbiac, 75013 Paris - France)
4
Centre of Oncology and Molecular Medicine (United Kingdom)
5
University of Dundee (University of Dundee
Nethergate
Dundee
Scotland, UK
DD1 4HN - United Kingdom)
6
I2MR - Institut de médecine moléculaire de Rangueil (Institut Louis Bugnard 1, avenue Jean Poulhes BP 84225 31432 TOULOUSE CEDEX 4 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
- IFR150 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U858 (101, rue de Tolbiac, 75013 Paris - France)
7
Department of Surgery and Molecular Oncology (DD1 9SY;Dundee - United Kingdom)
- University of Dundee (University of Dundee Nethergate Dundee Scotland, UK DD1 4HN - United Kingdom)
8
Department of Pathology [Dundee] (Dundee, DD1 9SY - United Kingdom)
- Ninewells Hospital and Medical School [Dundee] (Dundee Scotland, UK DD1 9SY - United Kingdom)
9
Dundee Cancer Center (DD1 9SY;Dundee - United Kingdom)
10
Cellules souches normales et cancéreuses (Hôpital Saint-Eloi, 80 av Augustin Fliche 34295 Montpellier Cedex 15 - France)
- UM1 - Université Montpellier 1 (5, boulevard Henri IV - CS 19044 - 34967 Montpellier cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1040 (101, rue de Tolbiac, 75013 Paris - France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
11
Department of Breast Surgical Oncology [Houston] (1840 Old Spanish Trail
Houston, TX 77054 - United States)
- The University of Texas M.D. Anderson Cancer Center [Houston] (1515 Holcombe Blvd. Houston, Texas 77030 - United States)
12
LIST - Laboratoire d'Intégration des Systèmes et des Technologies (DRT/LIST
Nano-INNOV
Avenue de la Vauve
91120 Palaiseau
- France)
- DRT (CEA) - Direction de Recherche Technologique (CEA) : DRT/LIST (France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRT (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
Abstract : TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, based on clinical analysis corroborated with experimental data, that the p53 isoform D133p53b promotes cancer cell invasion, regardless of TP53 mutation status. D133p53b increases risk of cancer recurrence and death in breast cancer patients. Furthermore D133p53b is critical to define invasiveness in a panel of breast and colon cell lines, expressing WT or mutant TP53. Endogenous mutant D133p53b depletion prevents invasiveness without affecting mutant full-length p53 protein expression. Mechanistically WT and mutant D133p53b induces EMT. Our findings provide explanations to 2 long-lasting and important clinical conundrums: how WT TP53 can promote cancer cell invasion and reciprocally why mutant TP53 gene does not systematically induce cancer progression.
Document type :
Journal articles
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https://hal.univ-reunion.fr/hal-01703040
Contributor : Réunion Univ <>
Submitted on : Thursday, June 28, 2018 - 11:09:06 AM
Last modification on : Monday, December 14, 2020 - 2:20:03 PM
Long-term archiving on: : Thursday, September 27, 2018 - 7:35:10 AM
Contributor : Réunion Univ <>
Submitted on : Thursday, June 28, 2018 - 11:09:06 AM
Last modification on : Monday, December 14, 2020 - 2:20:03 PM
Long-term archiving on: : Thursday, September 27, 2018 - 7:35:10 AM
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Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : hal-01703040, version 1
- DOI : 10.7554/eLife.14734
Collections
UNIV-REUNION | INSERM | LIST | UNIV-MONTPELLIER | BS | CEA-UPSAY | DRT | CNRS | CEA | PAPANGUE | UNIV-TLSE3
Citation
Gilles Gadéa, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien Joruiz, et al.. TP53 drives invasion through expression of its Δ133p53β variant. eLife, eLife Sciences Publication, 2016, 5, pp.e14734. ⟨10.7554/eLife.14734⟩. ⟨hal-01703040⟩
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