HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Abstract : Cancer stem cells (CSC) are responsible for cancer chemoresistance and metastasis formation. Here we report that D133p53b, a TP53 splice variant, enhanced cancer cell stemness in MCF-7 breast cancer cells, while its depletion reduced it. D133p53b stimulated the expression of the key pluripotency factors SOX2, OCT3/4, and NANOG. Similarly, in highly metastatic breast cancer cells, aggressiveness was coupled with enhanced CSC potential and D133p53b expression. Like in MCF-7 cells, SOX2, OCT3/4, and NANOG expression were positively regulated by D133p53b in these cells. Finally, treatment of MCF-7 cells with etoposide, a cytotoxic anti-cancer drug, increased CSC formation and SOX2, OCT3/4, and NANOG expression via D133p53, thus potentially increasing the risk of cancer recurrence. Our findings show that D133p53b supports CSC potential. Moreover, they indicate that the TP53 gene, which is considered a major tumor suppressor gene, also acts as an oncogene via the D133p53b isoform.
Complete list of metadata

Cited literature [21 references]  Display  Hide  Download

Contributor : Réunion Univ Connect in order to contact the contributor
Submitted on : Thursday, February 8, 2018 - 8:02:21 AM
Last modification on : Thursday, May 19, 2022 - 3:00:02 PM
Long-term archiving on: : Saturday, May 5, 2018 - 2:18:57 PM


Publication funded by an institution


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License



Nikola Arsic, Gilles Gadea, Ebba Louise Lagerqvist, Muriel Busson, Nathalie Cahuzac, et al.. The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential. Current Stem Cell Reports, Springer, 2015, 4 (4), pp.531-540. ⟨10.1016/j.stemcr.2015.02.001⟩. ⟨hal-01703033⟩



Record views


Files downloads