Unguiculin A and Ptilomycalins E–H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata - Université de La Réunion Access content directly
Journal Articles Journal of Natural Products Year : 2017

Unguiculin A and Ptilomycalins E–H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata

Abstract

Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E−H (2−5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM,
Fichier principal
Vignette du fichier
5- Campos et al., J nat Prod 2017_hal.pdf (2.57 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-01625266 , version 1 (27-10-2017)

Identifiers

Cite

Pierre-Éric Campos, Jean-Luc Wolfender, Emerson F. Queiroz, Laurence Marcourt, Ali Al-Mourabit, et al.. Unguiculin A and Ptilomycalins E–H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata. Journal of Natural Products, 2017, 80 (5), pp.1404 - 1410. ⟨10.1021/acs.jnatprod.6b01079⟩. ⟨hal-01625266⟩
222 View
326 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More