HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue.

Abstract : Dengue is a mosquito-borne viral disease that afflicts millions of individuals worldwide every year. Infection by any of the 4 dengue virus (DENV) serotypes can result in a spectrum of disease severity. We investigated the impact of variants of interferon-regulated innate immunity genes with a potent antiviral effect on the outcome of DENV infection. We compared the effect of OAS gene family variants on 2 DENV serotypes in cell culture. While both OAS1-p42 and p46 showed antiviral activity against DENV-2, only OAS1-p42 presented anti-DENV-1 activity. Conversely, whereas both OAS3_S381 and R381 variants were able to block DENV-1 infection, the anti-DENV-2 activity observed for OAS3_S381 was largely lost for the R381 variant. By means of an allelic association study of a cohort of 740 patients with dengue, we found a protective effect of OAS3_R381 against shock (odds ratio [OR], 0.37; P < .001). This effect was due to DENV-2 infections (OR, 0.13; P = .007) but was absent for DENV-1, in accordance with the serotype-dependent OAS3 activity found in the functional study. Severe dengue has long been associated with a cytokine storm of unclear origin. This work identifies an early innate immunity process that could lead to the immune overreaction observed in severe dengue and could be triggered by a specific host genotype-pathogen genotype interaction.
Document type :
Journal articles
Complete list of metadata

Cited literature [48 references]  Display  Hide  Download

https://hal.univ-reunion.fr/hal-01483426
Contributor : Réunion Univ Connect in order to contact the contributor
Submitted on : Wednesday, April 3, 2019 - 4:14:18 PM
Last modification on : Thursday, April 7, 2022 - 10:10:25 AM

File

jiv321.pdf
Publication funded by an institution

Licence

Copyright

Identifiers

Collections

Citation

Etienne Simon-Loriere, Ren-Jye Lin, Sita Mint Kalayanarooj, Ampaiwan Chuansumrit, Isabelle Casademont, et al.. High Anti-Dengue Virus Activity of the OAS Gene Family Is Associated With Increased Severity of Dengue.. Journal of Infectious Diseases, Oxford University Press (OUP), 2015, 212 (12), pp.2011-20. ⟨10.1093/infdis/jiv321⟩. ⟨hal-01483426⟩

Share

Metrics

Record views

167

Files downloads

114