, 0Á97 (0Á76?1Á24)
, 0Á83 (0Á64?1Á08) 1Á02 (0Á87?1Á19) 0Á84
, Adults, issue.1, 1934.
, <16 years) (n 1 = 670, Children
, Pregnant, pp.13-54
, Intensive care unit (ICU) patients (all ages) Adults (?16 years) (n 1 = 583
, Children, issue.1, pp.2-447
?2 days) versus later NAI (>2 days) Laboratory and clinically confirmed (all ages) (n 1 = 5058, p.925 ,
, 0Á46?0Á57)*** Laboratory-confirmed cases (all ages), p.667
, patients (all ages) Adults (?16 years) (n 1 = 1846, Adults (?16 years) (n 1 = 4189; n 2 = 7549)<16 years) (n 1 = 864; n 2 = 3295) 0Á43 (0Á29?0Á62)*** 0Á47 (0Á32?0Á71))*** Children (<16 years), pp.13-54
, Later (>2 days) versus no NAI treatment Laboratory and clinically confirmed (all ages) (n 1 = 3991, p.8251
, 1Á34?1Á84)*** Laboratory-confirmed cases (all ages)
, 1 = 3263, Adults, pp.1-28
, ICU patients Adults (?16 years) (n 1 = 1511; n 2 = 2249) 2Á35 (1Á31?4Á23)** 1Á55 (0Á83?2Á89) 1Á68 (1Á15?2Á46)** 1Á47, pp.1-1
, 1Á39?4Á96)** NAI anytime versus no NAI treatment Laboratory and clinically confirmed (all ages) (n 1 = 7975, 1Á08?1Á38)** Laboratory-confirmed cases (all ages))*** 1Á29 (1Á06?1Á57)* 1Á58 (1Á41?1Á78)*** 1Á19 (1Á05?1Á35)**, pp.164-165
, Adults (?16 years) (n 1 = 5964; n 2 = 13 247) 1Á53 (1Á24?1Á91)*** 1Á30 (1Á03?1Á63)* 1Á63 (1Á40?1Á89)*** 1Á24 (1Á06?1Á46)** Children (<16 years) (n 1 = 2005; n 2 = 6760) 1Á38 (1Á00?1Á90)* 1Á30, pp.0-92
, Pregnant, pp.13-54
, ICU patients (all ages) Adults (?16 years) (n 1 = 2721; n 2 = 4071) 2Á02 (1Á30?3Á14)** 1Á57 (1Á00?2Á48)* 1Á58 (1Á14?2Á18)** 1Á38, pp.1-1
, <16 years) (n 1 = 970; n 2 = 1579) 1Á45 (0Á89?2Á38) 1Á39 (0Á85?2Á29) 1Á76 (1Á22?2Á53)** 1Á59, pp.1-10
, n 1 = total number of patients included in IRP analysis; n 2 = total number of patients included in 'any pneumonia' analysis
?Influenza-related pneumonia and physician-diagnosed pneumonia. ? ?Adjusted for treatment propensity quintiles ,
,
Complications and Outcomes of Pandemic 2009 Influenza A (H1N1) Virus Infection in Hospitalized Adults: How Do They Differ From Those in Seasonal Influenza?, Journal of Infectious Diseases, vol.202, issue.6, pp.1739-1747, 2011. ,
DOI : 10.1086/655904
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico, New England Journal of Medicine, vol.361, issue.7, pp.680-689, 2009. ,
DOI : 10.1056/NEJMoa0904252
Risk factors of A/H1N1 etiology in pneumonia and its impact on mortality, Respiratory Medicine, vol.105, issue.9, pp.1404-1411, 2011. ,
DOI : 10.1016/j.rmed.2011.04.011
Factors Associated With Death or Hospitalization Due to Pandemic 2009 Influenza A(H1N1) Infection in California, JAMA, vol.302, issue.17, pp.1896-1902, 2009. ,
DOI : 10.1001/jama.2009.1583
URL : http://jama.jamanetwork.com/data/journals/jama/4486/joc90126_1896_1902.pdf
Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009), Thorax, vol.65, issue.7, pp.645-651, 2009. ,
DOI : 10.1136/thx.2010.135210
URL : http://europepmc.org/articles/pmc2921287?pdf=render
, Influenza antiviral medications: summary for clinicians, Centers for Disease Control and Prevention, 2014.
, Clinical management of human infection with pandemic (H1N1) 2009: Revised guidance, World Health Organization, 2009.
Impact of Oseltamivir Treatment on Influenza-Related Lower Respiratory Tract Complications and Hospitalizations, Archives of Internal Medicine, vol.163, issue.14, pp.1667-1672, 2003. ,
DOI : 10.1001/archinte.163.14.1667
Antivirals for Treatment of Influenza, Annals of Internal Medicine, vol.156, issue.7, pp.512-524, 2012. ,
DOI : 10.7326/0003-4819-156-7-201204030-00411
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children, Cochrane Database Syst Rev, vol.1, p.8965, 2012. ,
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children, Cochrane Database Syst Rev, vol.4, p.8965, 2014. ,
Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials, The Lancet, vol.385, issue.9979, pp.1729-1737, 2015. ,
DOI : 10.1016/S0140-6736(14)62449-1
Benefit of early treatment with oseltamivir in hospitalized patients with documented 2009 influenza A (H1N1): retrospective cohort study, Journal of Antimicrobial Chemotherapy, vol.31, issue.5, pp.1150-1155, 2011. ,
DOI : 10.2165/0002018-200831120-00006
Characteristics of pregnant Japanese women who required hospitalization for treatment of NAIs for influenza-related pneumonia ,
, The Authors Influenza and Other Respiratory Viruses Published by 203 pandemic (H1N1) 2009?low mortality rate may be due to early antiviral use, J Infect, vol.62, pp.232-233, 2011.
Pneumonia Complicating Pandemic (H1N1) 2009, Medicine, vol.90, issue.5, pp.328-336, 2011. ,
DOI : 10.1097/MD.0b013e31822e67a7
Reducing Occurrence and Severity of Pneumonia Due to Pandemic H1N1 2009 by Early Oseltamivir Administration: A Retrospective Study in Mexico, PLoS ONE, vol.50, issue.7, p.21838, 2011. ,
DOI : 10.1371/journal.pone.0021838.t005
Impact of Neuraminidase Inhibitor Treatment on Outcomes of Public Health Importance During the 2009-2010 Influenza A(H1N1) Pandemic: A Systematic Review and Meta-Analysis in Hospitalized Patients, Journal of Infectious Diseases, vol.67, issue.8, pp.553-563, 2013. ,
DOI : 10.1136/thoraxjnl-2011-200266
on behalf of the PRIDE Research Collaboration. Post-Pandemic Review of Anti-Influenza Drug Effectiveness, Pride Study): An Investigation of the Impact of Neuraminidase Inhibitor Antiviral Use on Pneumonia and Length of Hospital Stay in Hospitalized Influenza A (H1N1)pdm09 Patients [Abstract]. Riga: The European Scientific Workshop on Influenza (ESWI), 2014. ,
Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data, The Lancet Respiratory Medicine, vol.2, issue.5, pp.395-404, 2014. ,
DOI : 10.1016/S2213-2600(14)70041-4
URL : https://hal.archives-ouvertes.fr/hal-01274568
A systematic review of the impact of neuraminidase inhibitor antiviral use on outcomes of public health importance during the, ?ID=CRD42011001 273#.UvDWqFFNKW8, 2009. ,
, 21
Imaging of pneumonia: trends and algorithms, European Respiratory Journal, vol.18, issue.1, pp.196-208, 2001. ,
DOI : 10.1183/09031936.01.00213501
Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults, Thorax, vol.66, issue.3, pp.247-252, 2011. ,
DOI : 10.1136/thx.2010.151522
URL : https://thorax.bmj.com/content/66/3/247.full.pdf
Outcomes of adults hospitalised with severe influenza, Thorax, vol.65, issue.6, pp.510-515, 2010. ,
DOI : 10.1136/thx.2009.130799
URL : https://thorax.bmj.com/content/65/6/510.full.pdf
Treatment With Neuraminidase Inhibitors for Critically Ill Patients With Influenza A (H1N1)pdm09, Clinical Infectious Diseases, vol.201, issue.11, pp.1198-1204, 2012. ,
DOI : 10.1086/652498
URL : https://academic.oup.com/cid/article-pdf/55/9/1198/1196753/cis636.pdf
Antiviral Therapy and Outcomes of Influenza Requiring Hospitalization in Ontario, Canada, Clinical Infectious Diseases, vol.43, issue.4, pp.1568-1575, 2007. ,
DOI : 10.1086/505868
Effectiveness of Antiviral Treatment in Human Influenza A(H5N1) Infections: Analysis of a Global Patient Registry, The Journal of Infectious Diseases, vol.202, issue.8, pp.1154-1160, 2010. ,
DOI : 10.1086/656316
Antiviral Treatment for Patients Hospitalized with Severe Influenza Infection May Affect Clinical Outcomes, Clinical Infectious Diseases, vol.12, issue.8, pp.1323-1324, 2008. ,
DOI : 10.1086/520981
Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza, The Journal of Infectious Diseases, vol.200, issue.4, pp.492-500, 2009. ,
DOI : 10.1086/600383
Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:?? Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity, Journal of the American Chemical Society, vol.119, issue.4, pp.681-690, 1997. ,
DOI : 10.1021/ja963036t
Inhibition of neuraminidase activity by derivatives of 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, Virology, vol.58, issue.2, pp.457-463, 1974. ,
DOI : 10.1016/0042-6822(74)90080-4
Risk factors for mechanical ventilation in U.S. children hospitalized with seasonal influenza and 2009 pandemic influenza A*, Pediatric Critical Care Medicine, vol.13, issue.6, pp.625-631, 2012. ,
DOI : 10.1097/PCC.0b013e318260114e