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High leptospiremia is associated with low gamma–delta T cell counts

Loïc Raffray 1, 2, * Claude Giry 3, 1 Yoga Thirapathi 4 François Binois 4 Marie-Pierre Moiton 2 Marie Lagrange-Xelot 2 Dominique Ferrandiz 2 Marie-Christine Jaffar-Bandjee 3, 1 Philippe Gasque 1
* Corresponding author
1 PIMIT - Processus Infectieux en Milieu Insulaire Tropical
2 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
3 Microbiology Laboratory
4 GHER Groupe Hospitalier Est Réunion
Abstract : The role of innate immune cells either to mount appropriate defense mechanisms or to drive uncontrolled tissue injuries during acute leptospirosis is poorly understood. This study aimed at characterizing the selective mobilization of innate immune cells and the level of target organ injuries in response to leptospiremia. We focused on gamma-delta (γ-δ) T cells. Patients were prospectively assessed for cell count by cytometry, for bacterial load by PCR in plasma samples and for levels of soluble acute phase tissue enzymes. We found that the level of γ-δ T cells was low and inversely correlated to liver injuries and leptospiremia.
Keywords : Bacteremia Gamma–delta T cells antigen receptors Innate immunity Leptospirosis Liver
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Journal articles
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https://hal.univ-reunion.fr/hal-01200467
Contributor : Loic Raffray <>
Submitted on : Wednesday, September 16, 2015 - 2:58:57 PM
Last modification on : Thursday, March 28, 2019 - 11:24:17 AM

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Loïc Raffray, Claude Giry, Yoga Thirapathi, François Binois, Marie-Pierre Moiton, et al.. High leptospiremia is associated with low gamma–delta T cell counts. Microbes and Infection, Elsevier, 2015, 17 (6), pp.451-5. ⟨10.1016/j.micinf.2015.04.001⟩. ⟨hal-01200467⟩

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