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Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes

Evelyne Tarnus 1, 2 Hanny Wassef Jean-François Carmel Philippe Rondeau 1, 2 Marjolaine Roche 2 Jean Davignon Lise Bernier Emmanuel Bourdon 1, 2
1 GEICO - Groupe d'Etude sur l'Inflammation Chronique et l'Obésité
2 LBGM - Laboratoire de Biochimie et Génétique Moléculaire
Abstract : Oxidative stress in adipose tissue constitutes a pathological process involved in obesity-linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress. We first demonstrated that apoE secretion by adipocytes was stimulated by oxidative stress. We also observed that apoE overexpression protected adipocytes from hydrogen peroxide-induced damages, by mitigating intracellular oxidation and exerting extracellular antioxidant properties. Our findings clearly show a novel antioxidant role for apoE in adipose tissue.
Keywords : Antioxidant apolipoprotein E Human adipocytes Obesity Oxidative stress SW872
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https://hal.univ-reunion.fr/hal-01198349
Contributor : Nicolas Alarcon <>
Submitted on : Friday, September 11, 2015 - 9:06:40 PM
Last modification on : Thursday, March 28, 2019 - 11:24:15 AM

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Evelyne Tarnus, Hanny Wassef, Jean-François Carmel, Philippe Rondeau, Marjolaine Roche, et al.. Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes. FEBS Letters, Wiley, 2009, 583 (12), pp.2042--2048. ⟨10.1016/j.febslet.2009.05.016⟩. ⟨hal-01198349⟩

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