Salarins A and B and Tulearin A: New Cytotoxic Sponge-Derived Macrolides

Ashgan Bishara 1 Amira Rudi 1 Maurice Aknin 2 Drorit Neumann 3 Nathalie Ben-Califa 3 Yoel Kashman 1
1 School of Chemistry
2 LCSNSA - Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments
3 Sackler Faculty of Medicine
Abstract : Three novel nitrogenous macrolides designated salarin A (e.g. I) and B (II) and tulearin A were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compds. were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addn., I contains a triacylamine group and II a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compds. were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells. [on SciFinder(R)]
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Submitted on : Friday, August 28, 2015 - 3:08:28 PM
Last modification on : Monday, September 2, 2019 - 9:42:52 AM

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Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, et al.. Salarins A and B and Tulearin A: New Cytotoxic Sponge-Derived Macrolides. Organic Letters, American Chemical Society, 2008, 10 (2), pp.153--156. ⟨10.1021/ol702221v⟩. ⟨hal-01188152⟩

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