Salarins A and B and Tulearin A: New Cytotoxic Sponge-Derived Macrolides

Abstract : Three novel nitrogenous macrolides designated salarin A (e.g. I) and B (II) and tulearin A were isolated from the Madagascar Fascaplysinopsis sp. sponge. The structures of the compds. were elucidated by interpretation of MS and 1D and 2D NMR spectra. Both salarins carry an acetylcarbamate moiety, and in addn., I contains a triacylamine group and II a methoxymethylketone lactam. Tulearin A carries the naturally rare carbamate ester. The compds. were found to be toxic to brine shrimp larvae, and salarin A and tulearin A were also cytotoxic to leukemia cells. [on SciFinder(R)]