Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

Ashgan Bishara 1 Amira Rudi 1 Maurice Aknin 2 Drorit Neumann 3 Nathalie Ben-Califa 3 Yoel Kashman 1
1 School of Chemistry
2 LCSNSA - Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments
3 Sackler Faculty of Medicine
Abstract : Two closely related lipodepsipeptides, taumycins A and B (I and II) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compds. have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compds., likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data. [on SciFinder(R)]
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Submitted on : Friday, August 28, 2015 - 3:08:24 PM
Last modification on : Monday, September 2, 2019 - 9:42:52 AM

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Ashgan Bishara, Amira Rudi, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, et al.. Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp. Organic Letters, American Chemical Society, 2008, 10 (19), pp.4307--4309. ⟨10.1021/ol801750y⟩. ⟨hal-01188151⟩

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