Taumycins A and B, Two Bioactive Lipodepsipeptides from the Madagascar Sponge Fascaplysinopsis sp

Abstract : Two closely related lipodepsipeptides, taumycins A and B (I and II) have been isolated from the Madagascar sponge Fascaplysinopsis sp. The two compds. have the same 12-membered oxodepsipeptide ring system in common. Both were toxic to brine shrimp larvae, and taumycin A (1 μM), but not taumycin B, inhibited growth of the human UT-7 leukemic cell line. The structure of the two compds., likely to be derived from microorganisms, was established by MS and 1D and 2D NMR data. [on SciFinder(R)]