Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide

Ashgan Bishara 1 Amira Rudi 1 Israel Goldberg Maurice Aknin 2 Drorit Neumann 3 Nathalie Ben-Califa 3 Yoel Kashman 1
1 School of Chemistry
2 LCSNSA - Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments
3 Sackler Faculty of Medicine
Abstract : A novel nitrogenous bismacrolide, designated tausalarin C (I), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compd. was elucidated by interpretation of MS and 1- and 2-dimensional NMR spectra. It is suggested that tausalarin C is assembled from salarin A and pretaumycin A. The relative configuration of the chiral centers of salarin A was detd. by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed. [on SciFinder(R)]
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Submitted on : Friday, August 28, 2015 - 3:08:00 PM
Last modification on : Monday, September 2, 2019 - 9:42:52 AM

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Ashgan Bishara, Amira Rudi, Israel Goldberg, Maurice Aknin, Drorit Neumann, et al.. Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide. Organic Letters, American Chemical Society, 2009, 11 (16), pp.3538--3541. ⟨10.1021/ol9011019⟩. ⟨hal-01188143⟩

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