New lobane and cembrane diterpenes from two Comorian soft corals

Abstract : Preliminary biol. investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, resp. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compds. 1-3 were detd. by spectroscopic anal. and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
Document type :
Journal articles
Complete list of metadatas

Cited literature [42 references]  Display  Hide  Download

https://hal.univ-reunion.fr/hal-01188128
Contributor : Claire Tessier <>
Submitted on : Wednesday, June 6, 2018 - 8:30:05 AM
Last modification on : Thursday, October 10, 2019 - 11:38:05 AM
Long-term archiving on : Friday, September 7, 2018 - 12:41:18 PM

File

marinedrugs-08-00359.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Isabelle Bonnard, Sabina B. Jhaumeer-Laulloo, Nataly Bontemps, Bernard Banaigs, Maurice Aknin. New lobane and cembrane diterpenes from two Comorian soft corals. Marine drugs, MDPI, 2010, 8 (2), pp.359-372. ⟨10.3390/md8020359⟩. ⟨hal-01188128⟩

Share

Metrics

Record views

204

Files downloads

87