Role of proteins involved in epithelial integrity and polarity, regulated by (de)phosphorylation by Syk or PTPN13, in mammary tumour invasion
Résumé
The spleen tyrosine kinase (Syk) and tyrosine-protein phosphatase non-receptor type 13 (PTPN13) were described in hematopoietic cells with pro-oncogenic effects. Our team and others observed, however, that Syk and PTPN13 are also expressed in non-hematopoietic cells and established their role as tumor suppressors in mammary epithelial cells. To better understand their negative role in breast cancer, our team recently demonstrated a role of these proteins in cell junction stabilization (Hamyeh et al., Theranostics, 2020; Kassouf et al.,Cancers, 2019). However, the downstream signaling effectors of Syk and PTPN13 remain largely unknown.
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers produits par l'(les) auteur(s) |
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