MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System - Archive ouverte HAL Access content directly
Journal Articles International Journal of Molecular Sciences Year : 2022

MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System

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Marina Paiva Abuçafy
Regina Celia Galvao Frem
  • Function : Author
Giulia Polinario
  • Function : Author
  • PersonId : 1184831
Fernando Rogerio Pavan
Heng Zhao
  • Function : Author
  • PersonId : 1184833
Angelika Mielcarek
  • Function : Author
  • PersonId : 1184834
Cedric Boissiere
Christian Serre
Leila Aparecida Chiavacci
  • Function : Author

Abstract

Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment.
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hal-03847521 , version 1 (10-11-2022)

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Marina Paiva Abuçafy, Regina Celia Galvao Frem, Giulia Polinario, Fernando Rogerio Pavan, Heng Zhao, et al.. MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System. International Journal of Molecular Sciences, 2022, 23 (14), pp.7670. ⟨10.3390/ijms23147670⟩. ⟨hal-03847521⟩
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