Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data - IRT Saint Exupéry - Institut de Recherche Technologique
Preprints, Working Papers, ... Year : 2024

Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data

Abstract

Glioblastoma is a highly aggressive form of brain cancer characterized by rapid progression and poor prognosis. Despite advances in treatment, the underlying genetic mechanisms driving this aggressiveness remain poorly understood. In this study, we employed multimodal deep learning approaches to investigate glioblastoma heterogeneity using joint image/RNA-seq analysis. Our results reveal novel genes associated with glioblastoma. By leveraging a combination of whole-slide images and RNA-seq, as well as introducing novel methods to encode RNA-seq data, we identified specific genetic profiles that may explain different patterns of glioblastoma progression. These findings provide new insights into the genetic mechanisms underlying glioblastoma heterogeneity and highlight potential targets for therapeutic intervention.
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Dates and versions

hal-04746042 , version 1 (22-10-2024)

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  • HAL Id : hal-04746042 , version 1

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Ahmad Berjaoui, Louis Roussel, Eduardo Hugo Sanchez, Elizabeth Cohen-Jonathan Moyal. Uncovering the Genetic Basis of Glioblastoma Heterogeneity through Multimodal Analysis of Whole Slide Images and RNA Sequencing Data. 2024. ⟨hal-04746042⟩
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