MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection

Abstract : Author SummaryLeishmania parasites belong to different species, each one characterized by specific vectors and reservoirs, and causes cutaneous or visceral disease(s) of variable clinical presentation and severity. In its mammalian host, the parasite is an obligate intracellular pathogen infecting the monocyte/macrophage lineage. Leishmania have developed ambiguous relationships with macrophages. Indeed, these cells are the shelter of invading parasites, where they will grow and eventually will reside in a silent state for life. But macrophages are also the cells that participate, through the induction of several pro-inflammatory mediators and antigen presentation, to shape the host immune response and ultimately kill the invader. To subvert these anti-parasite responses, Leishmania manipulate the host machinery for their own differentiation and survival. We aimed to evaluate the impact of L. major (the causative agent of zoonotic cutaneous leishmaniasis) infection on deregulation of non-coding miRNAs, a class of important regulators of gene expression. Our results revealed the implication of several miRNAs on macrophage fate upon parasite infection through regulation of different pathways, including cell death. Our findings provided a new insight for understanding mechanisms governing this miRNA deregulation by parasite infection and will help to provide clues for the development of control strategies for this disease.
Type de document :
Article dans une revue
PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (10), pp.e2478. 〈10.1371/journal.pntd.0002478〉
Liste complète des métadonnées

http://hal.univ-reunion.fr/hal-01285440
Contributeur : Réunion Univ <>
Soumis le : mercredi 9 mars 2016 - 11:26:20
Dernière modification le : vendredi 24 novembre 2017 - 15:16:03

Identifiants

Collections

Citation

Julien Lemaire, Ghada Mkannez, Fatma Z. Guerfali, Cindy Gustin, Hanène Attia, et al.. MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection. PLoS Neglected Tropical Diseases, Public Library of Science, 2013, 7 (10), pp.e2478. 〈10.1371/journal.pntd.0002478〉. 〈hal-01285440〉

Partager

Métriques

Consultations de la notice

53