Regulation of type I-interferon responses in the human epidermal melanocyte cell line SKMEL infected by the Ross River alphavirus

Abstract : Melanocytes are melanin-producing cells and with emerging innate immune functions including the expression of antiviral interferon-type I cytokines. We herein ascertained the susceptibility of the human melanocytes to Ross River alphavirus (RRV) infection and analyzed the subsequent immune responses. We demonstrated for the first time that (1) SKMEL-28 melanocyte cell line was susceptible to RRV infection and displaying major cytopathic activities and (2) RRV interfered with the interferon-type I response by altering nuclear translocation of pSTAT1 and pSTAT2 in infected SKMEL-28. These results suggest that the human melanoma cell line SKMEL-28 is a valuable model to analyze the mechanisms involved in severe skin manifestations and melanocyte’s immunity at the portal of entry of major infection by arboviruses.
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http://hal.univ-reunion.fr/hal-01285423
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Soumis le : mercredi 9 mars 2016 - 11:25:45
Dernière modification le : dimanche 5 novembre 2017 - 15:58:08

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Mohamad Assi, Vincent G. Thon-Hon, Marie-Christine Jaffar-Bandjee, Audrey Martinez, Philippe Gasque. Regulation of type I-interferon responses in the human epidermal melanocyte cell line SKMEL infected by the Ross River alphavirus. Cytokine, 2015, 〈10.1016/j.cyto.2015.07.003〉. 〈hal-01285423〉

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