Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection

Abstract : To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.
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Submitted on : Tuesday, February 16, 2016 - 8:41:07 AM
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Duksha Ramful, Sylvain Samperiz, Xavier Fritel, Alain Michault, Marie-Christine Jaffar-Bandjee, et al.. Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection. Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 209 (11), pp.1726--1730. ⟨10.1093/infdis/jit814⟩. ⟨hal-01274572⟩

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