Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection

Abstract : To search for serological evidence of congenital infection in apparently healthy neonates born to women infected with the Chikungunya virus (CHIKV) during pregnancy, monitoring for CHIKV-specific antibodies was performed within the CHIMERE cohort study (Reunion island, 2006-2008). CHIKV-specific antibody kinetics showed no evidence of asymptomatic congenital infection as neonates were tested negative for CHIKV-specific IgM antibodies at birth and 368 infants with CHIKV-specific IgG antibodies seroreversed completely (mean seroreversion time: 7.7 months). Seroreversion time of transplacental CHIKV IgG antibodies was inversely correlated with the stage of pregnancy at which exposure took place and end-term small for gestational infants seroreversed earlier.
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The Journal of Infectious Diseases, 2014, 209 (11), pp.1726--1730. 〈10.1093/infdis/jit814〉
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http://hal.univ-reunion.fr/hal-01274572
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Soumis le : mardi 16 février 2016 - 08:41:07
Dernière modification le : dimanche 5 novembre 2017 - 15:58:05

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Duksha Ramful, Sylvain Samperiz, Xavier Fritel, Alain Michault, Marie-Christine Jaffar-Bandjee, et al.. Antibody kinetics in infants exposed to Chikungunya virus infection during pregnancy reveals absence of congenital infection. The Journal of Infectious Diseases, 2014, 209 (11), pp.1726--1730. 〈10.1093/infdis/jit814〉. 〈hal-01274572〉

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