Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide

Abstract : A novel nitrogenous bismacrolide, designated tausalarin C (I), was isolated from the Madagascar sponge Fascaplysinopsis sp. The structure of the compd. was elucidated by interpretation of MS and 1- and 2-dimensional NMR spectra. It is suggested that tausalarin C is assembled from salarin A and pretaumycin A. The relative configuration of the chiral centers of salarin A was detd. by X-ray diffraction. Tausalarin C was found to inhibit proliferation of K562 leukemia cells. A possible biogenesis is discussed. [on SciFinder(R)]
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Organic Letters, American Chemical Society, 2009, 11 (16), pp.3538--3541. 〈10.1021/ol9011019〉
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http://hal.univ-reunion.fr/hal-01188143
Contributeur : Claire Tessier <>
Soumis le : vendredi 28 août 2015 - 15:08:00
Dernière modification le : vendredi 14 septembre 2018 - 08:16:30

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Ashgan Bishara, Amira Rudi, Israel Goldberg, Maurice Aknin, Drorit Neumann, et al.. Tausalarin C: A New Bioactive Marine Sponge-Derived Nitrogenous Bismacrolide. Organic Letters, American Chemical Society, 2009, 11 (16), pp.3538--3541. 〈10.1021/ol9011019〉. 〈hal-01188143〉

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