Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Abstract : Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
Type de document :
Article dans une revue
Marine drugs, MDPI, 2013, 11 (11), pp.4487--4509. 〈10.3390/md11114487〉
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http://hal.univ-reunion.fr/hal-01188114
Contributeur : Claire Tessier <>
Soumis le : vendredi 28 août 2015 - 15:06:29
Dernière modification le : dimanche 5 novembre 2017 - 15:58:05

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Lee G. Zur, Ashgan Bishara, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, et al.. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Marine drugs, MDPI, 2013, 11 (11), pp.4487--4509. 〈10.3390/md11114487〉. 〈hal-01188114〉

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