Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites

Abstract : Derivatives of salarin A, salarin C and tulearin A, three new cytotoxic sponge derived nitrogenous macrolides, were prepared and bio-evaluated as inhibitors of K562 leukemia cells. Interesting preliminary SAR (structure activity relationship) information was obtained from the products. The most sensitive functionalities were the 16,17-vinyl epoxide in both salarins, the triacylamino group in salarin A and the oxazole in salarin C (less sensitive). Regioselectivity of reactions was also found for tulearin A.
Document type :
Journal articles
Liste complète des métadonnées

http://hal.univ-reunion.fr/hal-01188114
Contributor : Claire Tessier <>
Submitted on : Tuesday, June 19, 2018 - 3:25:26 PM
Last modification on : Thursday, March 28, 2019 - 11:24:13 AM
Document(s) archivé(s) le : Tuesday, September 25, 2018 - 10:58:28 PM

File

Derivatives_of_salarin.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Lee G. Zur, Ashgan Bishara, Maurice Aknin, Drorit Neumann, Nathalie Ben-Califa, et al.. Derivatives of Salarin A, Salarin C and Tulearin A—Fascaplysinopsis sp. Metabolites. Marine drugs, MDPI, 2013, 11 (11), pp.4487-4509. ⟨10.3390/md11114487⟩. ⟨hal-01188114⟩

Share

Metrics

Record views

88

Files downloads

12